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ABCB9

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ABCB9
Identifiers
AliasesABCB9, EST122234, TAPL, ATP binding cassette subfamily B member 9
External IDsOMIM: 605453; MGI: 1861729; HomoloGene: 10491; GeneCards: ABCB9; OMA:ABCB9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019875

RefSeq (protein)

NP_001229942
NP_001229943
NP_062570
NP_062571
NP_982269

NP_063928

Location (UCSC)Chr 12: 122.92 – 122.98 MbChr 5: 124.2 – 124.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ABCB9 gene.[5][6]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150967Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029408Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  6. ^ a b "Entrez Gene: ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.