ICE (chemotherapy)
(Redirected from ICE chemotherapy regimen)
ICE in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-Hodgkin's lymphoma and Hodgkin lymphoma.
In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab. This regimen is then called ICE-R or R-ICE or RICE.
[R]-ICE regimen consists of:[citation needed]
- Rituximab - an anti-CD20 monoclonal antibody, which is able to kill both normal and malignant CD20-bearing B cells;
- Ifosfamide - an alkylating antineoplastic agent of the oxazafosforine group;
- Carboplatin - a platinum-based antineoplastic drug, also an alkylating antineoplastic agent;
- Etoposide - a topoisomerase inhibitor.
Dosing regimen
[edit]| Drug | Dose | Mode | Days |
|---|---|---|---|
| Rituximab | 375 mg/m2 | IV infusion | Day 1 |
| Ifosfamide | 5000 mg/m2 | IV continuous infusion over 24 hours | Day 2 |
| Mesna for haemorrhagic cystitis prophylaxis with ifosfamide | 5000 mg/m2 | IV continuous infusion over 24 hours | Day 2 |
| Carboplatin | Optimized to get AUC = 5 (max. 800 mg) | IV infusion | Day 2 |
| Etoposide | 100 mg/m2 | IV infusion over 1 hour | Days 1-3 |
| Filgrastim to shorten the period of neutropenia | 5 μg/kg | S.C. | Days 5-12 |
Cycles are repeated every 14 days for 3 cycles, then high-dose chemotherapy with autologous stem-cell transplantation follows (if the patient is considered eligible for HDCT and ASCT).[1][2]
References
[edit]- ^ Ifosfamide, Carboplatin, and Etoposide: A Highly Effective Cytoreduction and Peripheral-Blood Progenitor-Cell Mobilization Regimen for Transplant-Eligible Patients With Non-Hodgkin’s Lymphoma
- ^ Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma