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Mitochondrial myopathy

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Mitochondrial myopathy
Other namesMitochondrial muscle disease; muscle mitochondrinopathy; muscle mitochondrial dysfunction
Simplified structure of a typical mitochondrion
SpecialtyNeuromuscular medicine

Mitochondrial myopathies are types of myopathies associated with mitochondrial disease.[1] Adenosine triphosphate (ATP), the chemical used to provide energy for the cell, cannot be produced sufficiently by oxidative phosphorylation when the mitochondrion is either damaged or missing necessary enzymes or transport proteins. With ATP production deficient in mitochondria, there is an over-reliance on anaerobic glycolysis which leads to lactic acidosis either at rest or exercise-induced.[2]

Primary mitochondrial myopathies are inherited, while secondary mitochondrial myopathies may be inherited (e.g. Duchenne's muscular dystrophy)[3] or environmental (e.g. alcoholic myopathy[4][5]). When it is an inherited primary disease, it is one of the metabolic myopathies.[6][4]

On biopsy, the muscle tissue of patients with these diseases usually demonstrate "ragged red" muscle fibers on Gomori trichrome staining. The ragged-red appearance is due to a buildup of abnormal mitochondria underneath the plasma membrane.[7] These ragged-red fibres may contain normal or abnormally increased accumulations of glycogen and neutral lipids, with histochemical staining showing abnormal respiratory chain involvement, such as decreased succinate dehydrogenase or cytochrome c oxidase.[8] Inheritance was believed to be maternal (non-Mendelian extranuclear). It is now known that certain nuclear DNA deletions can also cause mitochondrial myopathy such as the OPA1 gene deletion.[6]

Signs and symptoms

[edit]

Proximal muscle weakness, exercise intolerance, lactic acidosis, high serum lactate/pyruvate ratio, normal to elevated serum CK, dyspnea, exaggerated cardiorespiratory response to exercise are common symptoms. It may be isolated to the muscle (pure myopathy) or may be systemic including not only myopathy, but also eye abnormalities, peripheral neuropathy, and neurological abnormalities. Muscle biopsy typically shows ragged-red fibres, histochemical staining shows abnormality of respiratory chain or decreased cytochrome c oxidase (COX).[9][10]

The five most common are MELAS, MERF, KSS, CPEO, and MNGIE which are listed below:[9]

Cause

[edit]
Many mitochondrial myopathies have mitochondrial inheritance

Mitochondrial myopathy literally means mitochondrial muscle disease, muscle disease caused by mitochondrial dysfunction. The mitochondrion is the primary producer of energy in nearly all cells throughout the body. The exception is mature erythrocytes (red blood cells), so that they do not use up the oxygen that they carry. In the eye, the lens and outer segment of the retina contain almost no mitochondria. Muscle cells have many mitochondria, particularly type I muscle fibres, and if the mitochondria have problems by which they do not produce enough energy for the cell to function, problems occur.[11]

The cause may be genetic, with many having mitochondrial inheritance (involving the mitochondrial DNA which is only passed on from the mother), although nuclear DNA mutations with Mendelian inheritance that are either autosomal dominant, recessive, or X-linked recessive also exist. A nuclear DNA example is a mutation within the POLG (polymerase gamma) gene, which causes mitochondrial DNA (mtDNA) to become damaged and lose function.

Disease list

[edit]
This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.
Name

(alternate names)

Gene(s) Inheritance pattern

(MT, AR, AD, X-Linked)

OMIM #

(GD: gene description, PS: phenotypic series)

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like syndrome (MELAS)

(Juvenile myopathy, encephalopathy, lactic acidosis and stroke)

MT-TL1, MT-TQ, MT-TH, MT-TK, MT-TC, MT-TS1, MT-ND1, MT-ND5, MT-ND6, MT-TS2 MT 540000[12]
Myoclonic epilepsy and ragged-red fibers (MERRF) MT-TK, MT-TL1, MT-TH, MT-TS1, MT-TS2, MT-TF MT 545000[13]
Kearns–Sayre syndrome (KSS)

(Ophthalmoplegia, pigmentary degeneration of retina, and cardiomyopathy; oculocraniosomatic syndrome; ophthalmoplegia-plus syndrome; mitochondrial cytopathy, ophthalmoplegia, progressive external, with ragged-red fibers; chronic progressive external ophthalmoplegia with myopathy; CPEO with myopathy; CPEO with ragged-red fibers)

MT-TL1 MT 530000[14]
Chronic progressive external ophthalmoplegia (CPEO)

(Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive/dominant)

POLG, SLC25A4, RNASEH1, TWNK, TK2, POLG2, DGUOK, TOP3A, RRM2B AR/AD PS157640[15]
Mitochondrial DNA depletion syndrome (MNGIE type)

(Mitochondrial neurogastrointestinal encephalopathy (MNGIE); myoneurogastrointestinal encephalopathy syndrome; polyneuropathy, ophthalmoplegia, leukoencephalopathy, and intestinal pseudoobstruction; POLIP syndrome)

TYMP, RRM2B, POLG, LIG3 AR 603041;

612075;

613662;

619780[16]

Mitochondrial DNA depletion syndrome

(Alpers type, cardiomyopathic type, encephalomyopathic type, hepatocerebral type, and myopathic type)

MGME1, SLC25A10, TK2, POLG, SLC25A21, SUCLA2, TWNK, TFAM, AGK, MRM2, SLC25A4, OPA1, SUCLG1 AR/AD PS603041[16]
Mitochondrial myopathy, infantile, transient (MMIT)

(Mitochondrial myopathy, infantile, transient, due to respiratory chain deficiency; COX deficiency myopathy, infantile, transient; respiratory chain deficiency, infantile, transient)

MT-TE MT 500009[17]
Mitochondrial myopathy, lethal, infantile (LIMM)

(Lethal infantile mitochondrial myopathy)

MT-TT MT 551000[18]
Hereditary myopathy with lactic acidosis (HML)

(Myopathy with exercise intolerance, Swedish type; myopathy with deficiency of succinate dehydrogenase and aconitase; myoglobinuria due to abnormal glycolysis; Larsson–Linderholm syndrome; Linderholm myopathy)

ISCU AR/AD[19] 255125[20]
Mitochondrial myopathy with diabetes

(Mitochondrial myopathy, lipid type)

MT-TE MT 500002[21]
Maternally inherited diabetes and deafness (MIDD)

(Diabetes and deafness (DAD); Ballinger–Wallace syndrome; Noninsulin-dependent diabetes mellitus with deafness, maternally inherited)

MT-TL1, MT-TE, MT-TK MT 520000[22]
Myopathy, mitochondrial progressive, with congenital cataract and developmental delay (MPMCD)

(Myopathy with cataract and combined respiratory chain deficiency; mitochondrial complex deficiency, combined)

GFER AR 613076[23]
Myopathy, lactic acidosis, and sideroblastic anemia (MLASA)

(Mitochondrial myopathy and sideroblastic anemia)

PUS1, YARS2, MT-ATP6 AR/MT 600462

613561[24]

GD: 516060[25]

Myopathy, isolated mitochondrial, autosomal dominant (IMMD) CHCHD10 AD 616209[26]
Myopathy, mitochondrial, and ataxia (MMYAT) MSTO1 AR/AD 617675[27]
Mitochondrial myopathy, episodic, with or without optic atrophy and reversible leukoencephalopathy (MEOAL) FDX2 AR 251900[28]
Mitochondrial myopathy with lactic acidosis (MMLA) PNPLA8 AR 251950[29]
Mitochondrial myopathy with a defect in mitochondrial-protein transport Unknown AR 251945[30]
Myotonic dystrophy-like myopathy;

Mitochondrial myopathy

MT-TA MT GD: 590000[31]
Mitochondrial myopathy, isolated MT-TD MT GD: 590015[32]
Myopathy, mitochondrial MT-TW MT GD: 590095[33]
Barth Syndrome (BTHS)

(Cardioskeletal myopathy with neutropenia and abnormal mitochondria; 3-methylglutaconic aciduria, type II; MGCA2; MGA, type II; MGA2)

TAFAZZIN X-Linked 302060[34]
Coenzyme Q10 deficiency, primary (COQ10D)

(CoQ10 deficiency, primary; ubiquinone deficiency; Coenzyme Q deficiency; CoQ deficiency)

COQ2, PDSS1, PDSS2, ADCK3, COQ9, COQ4, COQ7, COQ5 AR PS607426[35]
Mitochondrial complex I deficiency, nuclear type (MC1DN)

(NADH:Q(1) oxidoreductase deficiency; NADH-coenzyme Q reductase deficiency; mitochondrial NADH dehydrogenase component of complex I, deficiency of)

NDUFS2, NDUFB3, NDUFS1, NDUFA10, NDUFAF3, TIMMDC1, ACAD9, NDUFS6, NDUFS4, NDUFAF2, NDUFA2, NDUFAF4, DNAJC30, NDUFAF6, NDUFB9, NDUFA8, NDUFB8, NDUFS3, NDUFV1, NDUFS8, NDUFC2, TMEM126B, FOXRED1, NDUFA9, NDUFA12, NUBPL, NDUFAF1, MTFMT, NDUFB10, NDUFAF8, NDUFV2, NDUFS7, NDUFA11, NDUFB7, NDUFA13, NDUFAF5, NDUFA6, NDUFB11, NDUFA1 AR/XL/XLR PS252010[36]
Mitochondrial complex II deficiency, nuclear type (MC2DN)

(Succinate CoQ reductase deficiency; succinate dehydrogenase deficiency)

SDHA, SDHAF1, SDHD, SDHB AR PS252011[37]
cytochrome b of complex III (MTCYB);

Exercise intolerance; multisystem disorder; cardiomyopathy, infantile histiocytoid; exercise intolerance, cardiomyopathy, and septooptic dysplasia; parkinsonism/MELAS overlap syndrome

MT-CYB MT GD: 516020[38]
Mitochondrial complex III deficiency, nuclear type (MC3DN) BCS1L, TTC19, UQCRQ, UQCRC2, CYC1, UQCC2, LYRM7, UQCC3, UQCRFS1 AR PS124000[39]
Mitochondrial complex IV deficiency, nuclear type (MC4DN)

(mitochondrial complex IV deficiency; cytochrome c oxidase deficiency; COX deficiency)

SURF1, SCO2, COX10, SCO1, LRPPRC, COX15, COX6B1, TACO1, COX14, COX20, PET100, COA6, COA3, COX8A, COX4I1, APOPT1, COX6A2, PET117, COX5A, COXFA4, COX16, COX11 AR PS220110[40]
Mitochondrial complex V (ATP synthase) deficiency, nuclear type (MC5DN) ATPAF2, TMEM70, ATP5E, ATP5F1A, ATP5F1D, ATP5MD, ATP5PO AR/AD PS604273[41]
Muscular dystrophy, limb-girdle, type 1H

(As of 2017 was excluded from LGMD for showing histochemical evidence of being a mitochondrial myopathy, but not yet assigned new nomenclature)[42][43]

Chromosome 3 (3p23-p25), unknown gene AD 613530[44]

Diagnosis

[edit]
Very high magnification micrograph showing ragged red fibres in a mitochondrial myopathy. Gömöi trichrome stain.

Muscle biopsy: usually ragged red fibres in Gömöri trichrome stain, normal or excessive glycogen or lipid accumulation within these ragged red fibres, histochemical staining showing impairment of respiratory chain such as COX-negative fibres.[6][8] Some mitochondrial myopathies are limited to disease expression only in skeletal muscle, with fibroblasts (from skin biopsy) appearing normal.[45][19]

Blood tests: lactate/pyruvate ratio may be elevated or normal, creatine kinase (CK) may be elevated or normal.[6][2] Electrolyte panel, anion gap, glucose, vitamin D, TSH, anti-HMGCR and AChR autoantibodies to rule-out pseudometabolic myopathies.[6][2]

Exercise stress test: exaggerated cardiorespiratory response to exercise (inappropriate rapid heart rate response to exercise with breathlessness [tachycardia and dyspnea]).[10]

DNA tests: whole exome sequencing (WES) neuromuscular panels (that only test exons), or whole genome sequencing (WGS) for more complex cases (that test exons, introns, and mitochondrial DNA). Introns were initially thought to be "junk DNA," however, some introns regulate the expression of exons.[46][47] For example, in the mitochondrial myopathy of hereditary myopathy with lactic acidosis (HML), the most common pathogenic mutation is the intronic IVS5+382 G>C (rs767000507).[19]

There are two groups of DNA that affect the mitochondria: mitochondrial genome (mtDNA) and nuclear DNA.[6] For mitochondrial myopathies that involve a single mtDNA deletion, it would only be found on muscle-derived mtDNA, making a biopsy of affected muscle necessary for DNA analysis rather than saliva or blood.[6][8] Even among siblings with the same inherited mutation, different muscle groups were affected, with unaffected tissues having near normal levels of mtDNA.[48][49]

EMG: may be normal, myopathic, or rarely neurogenic.[6]

The symptoms of exercise intolerance, abnormal muscle fatigue, myalgia (muscle pain), arrhythmia, possible fixed proximal muscle weakness, lipid deposits, possible episodes of rhabdomyolysis, with symptoms becoming evident or worsening while fasting, during a fever, during low-intensity aerobic activity or after prolonged activity–all these overlap with the symptoms of another metabolic myopathy, that of fatty acid metabolism disorders.[6]

DNA testing is helpful for determining between the similar presenting, but different in bioenergetic system origin, metabolic myopathies. When DNA testing is inconclusive, a muscle biopsy is necessary.[2][6][8]

Differential diagnosis

[edit]

Diseases that mimic the symptoms of mitochondrial myopathy include electrolyte imbalance, myasthenia gravis, thyroid abnormalities, vitamin D deficiency, immune-mediated necrotizing myopathy, diabetes-related pseudohypoxia, and fatty acid metabolism disorders.[6][2] Hypoxia due to ischemia (insufficient blood flow) also impairs oxidative phosphorylation, which can be seen in intermittent claudication, chronic venous insufficiency, and popliteal artery entrapment syndrome. If symptoms of muscle fatigue improve after approximately 10 minutes of low-moderate intensity aerobic exercise, or after approximately 10 minutes of rest following aerobic exercise, this would be indicative of the second wind phenomenon seen in select muscle glycogenoses.[2]

Ragged red fibres (a mitochondrial abnormality) can be found in a number of myopathies other than the inherited primary mitochondrial myopathies.[50] These include axonal Charcot–Marie–Tooth disease types 2CC & 2EE, congenital myasthenic syndrome types 12 & 14, congenital myopathy types 10B & 22A, and MYH7-related myopathies such as Laing distal myopathy and myosin storage myopathy.[50]

Secondary mitochondrial myopathy can be caused by natural aging,[51][52] inflammatory myopathies,[51] and chronic alcohol use disorder.[4][5] It can also be due to certain drugs such statins, bupivacaine, antiepileptic drugs (phenytoin, valproic acid, and lamotrigine), and nucleoside reverse transcriptase inhibitors (antiviral drugs) such as zidovudine and clevudine.[53]

Some metabolic myopathies affect multiple bioenergetic pathways, for instance multiple acyl-CoA dehydrogenase deficiency (MADD), formerly known as glutaric acidemia type II (GA-II). The ETF genes involved in MADD impairs beta oxidation (fatty acid metabolism), impairs amino acid catabolism (protein metabolism), and simultaneously impairs the respiratory chain by not transferring electrons from reduced FAD+/FADH2. The impaired protein metabolism leads to a buildup of glutaric acid and other acids. Fatty acid metabolism is further impaired as carnitine is used to detoxify the buildup of glutaric acid, causing secondary carnitine deficiency.[54][55] Although MADD affects multiple bioenergetic pathways, it is classified as a fatty acid metabolism disorder as that is the bioenergetic pathway that is affected the most by the deficiency. However, it is important to note as a differential diagnosis as not only do the symptoms overlap with mitochondrial myopathies, but also muscle biopsies of some individuals with MADD show COX-negative fibres, respiratory chain impairment, and deficiency of coenzyme Q10.[56][57] Some forms of MADD respond well to riboflavin (vitamin B2), known as riboflavin-responsive MADD (RR-MADD).[6]

Riboflavin-responsive exercise intolerance (RREI), a fatty acid metabolism disorder involving the SLC25A32 gene, has symptoms similar to MADD, with muscle biopsy showing ragged red fibres and lipid deposits (mainly in type I fibres), small type II fibres, and impaired FAD-dependent mitochondrial respiratory chain.[58]

Myopathies involving abnormal autophagy, including abnormal mitophagy, may present with secondary impaired fatty acid metabolism and/or mitochondrial defects in skeletal muscles, may have wide phenotypic variability, and may affect multiple other organs. For instance, EPG5-related Vici syndrome and TANGO2-related disease.[59][60] TANGO2-related disease is at least partially responsive to B vitamin supplementations of panthotenic acid (B5) and folate (B9).[60][61]

Pompe disease (glycogen storage disease type II), another type of metabolic myopathy, has secondary mitochondrial dysfunction present in both the earlier onset forms (infantile and juvenile) and the late-onset form in adults.[62]

Myopathies involving the DMD gene, such as Duchenne and Becker muscular dystrophy, have secondary mitochondrial dysfunction impairing oxidative phosphorylation.[3][63] The mechanisms leading to this mitochondrial dysfunction are many and it has yet to be elucidated which mitochondrial changes are directly due to the disease and which are compensatory.[3] Three unrelated young boys, with a mutation in the DMD gene, exhibited a pseudometabolic presentation with symptoms of exercise intolerance manifesting as exercise-induced myalgia, muscle stiffness, myoglobinuria and rhabdomyolysis.[64]

A few Limb–girdle muscular dystrophies are known to have secondary mitochondrial dysfunction, including: LGMDR1 calpain3-related (formerly LGMD 2A), LGMDR2 dysferlin-related (LGMD 2B), LGMDR3 α-sarcoglycan-related (LGMD 2D), LGMDR5 γ-sarcoglycan-related (LGMD 2C), and LGMDR6 δ-sarcoglycan-related (LGMD 2F).[63][65] As well as Myofibrillar myopathy 8 (MFM8) PYROXD1-related, which has an adult-onset, slowly progressive, Limb–girdle phenotype.[63][66]

MICU1-related myopathy with extrapyramidal signs has disrupted calcium uptake causing secondary mitochondrial dysfunction. It has variable myopathic features as well as eye and neurological symptoms.[67]

Treatment

[edit]

Although no cure currently exists, there is hope in treatment for this class of hereditary diseases as trials continue.

Aerobic training may improve oxidative capacity by the skeletal muscles becoming aerobically conditioned. Deoxynucleoside monophosphates and deoxynucleotide taken orally, may help in TK2 deficiency (Mitochondrial DNA depletion syndrome 2 myopathic type).[6]

Avoiding physically stressful situations that deplete glycogen reserves, such as fasting and endurance exercise (which rely predominantly on oxidative phosphorylation), may help. A high-carb/low-fat/low-protein diet may help.[6]

See also

[edit]

References

[edit]
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  26. ^ "616209 - MYOPATHY, ISOLATED MITOCHONDRIAL, AUTOSOMAL DOMINANT; IMMD". www.omim.org. Retrieved 2023-11-30.
  27. ^ "#617675 - MYOPATHY, MITOCHONDRIAL, AND ATAXIA; MMYAT". www.omim.org. Retrieved 2023-11-30.
  28. ^ "#251900 - MITOCHONDRIAL MYOPATHY, EPISODIC, WITH OR WITHOUT OPTIC ATROPHY AND REVERSIBLE LEUKOENCEPHALOPATHY; MEOAL". www.omim.org. Retrieved 2023-11-30.
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  31. ^ "*590000 - TRANSFER RNA, MITOCHONDRIAL, ALANINE; MTTA". www.omim.org. Retrieved 2023-11-30.
  32. ^ "*590015 - TRANSFER RNA, MITOCHONDRIAL, ASPARTIC ACID; MT-TD". www.omim.org. Retrieved 2023-11-30.
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