NAIP (gene)

NAIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VM5
Identifiers
Aliases	NAIP, BIRC1, NLRB1, psiNLR family, apoptosis inhibitory protein, NLR family apoptosis inhibitory protein
External IDs	OMIM: 600355; MGI: 1298226; HomoloGene: 136092; GeneCards: NAIP; OMA:NAIP - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q13.2 Start 70,968,166 bp End 71,025,339 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 D1|13 53.01 cM Start 100,280,571 bp End 100,338,600 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spleen granulocyte appendix bone marrow cells right uterine tube epithelium of colon ganglionic eminence right lung blood Top expressed in granulocyte left colon ileum Paneth cell jejunum epithelium of small intestine intestinal villus duodenum urethra male urethra More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity nucleotide binding cysteine-type endopeptidase inhibitor activity metal ion binding ubiquitin-protein transferase activity protein binding ATP binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process Cellular component perikaryon soma basolateral plasma membrane neuron projection cytoplasm nucleus Biological process negative regulation of neuron apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to amino acid negative regulation of peptidase activity immune system process nervous system development response to axon injury innate immune response inflammatory response apoptotic process protein ubiquitination positive regulation of canonical Wnt signaling pathway mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4671 17948 Ensembl ENSG00000278613 ENSG00000276068 ENSG00000249437 ENSMUSG00000078945 UniProt Q13075 Q9QUK4 RefSeq (mRNA) NM_004536 NM_022892 NM_001346870 NM_001126182 NM_010872 RefSeq (protein) NP_001333799 NP_004527 NP_075043 NP_001119654 NP_035002 Location (UCSC) Chr 5: 70.97 – 71.03 Mb Chr 13: 100.28 – 100.34 Mb PubMed search
Wikidata
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Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Further reading

• van der Steege G, Draaijers TG, Grootscholten PM, et al. (1995). "A provisional transcript map of the spinal muscular atrophy (SMA) critical region". Eur. J. Hum. Genet. 3 (2): 87–95. doi:10.1159/000472281. PMID 7552146. S2CID 46083524.
• Liston P, Roy N, Tamai K, et al. (1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature. 379 (6563): 349–53. Bibcode:1996Natur.379..349L. doi:10.1038/379349a0. PMID 8552191. S2CID 4305853.
• Chen Q, Baird SD, Mahadevan M, et al. (1998). "Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP". Genomics. 48 (1): 121–7. doi:10.1006/geno.1997.5141. PMID 9503025.
• Monani UR, Lorson CL, Parsons DW, et al. (1999). "A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2". Hum. Mol. Genet. 8 (7): 1177–83. doi:10.1093/hmg/8.7.1177. PMID 10369862.
• Yamamoto K, Sakai H, Hadano S, et al. (1999). "Identification of two distinct transcripts for the neuronal apoptosis inhibitory protein gene". Biochem. Biophys. Res. Commun. 264 (3): 998–1006. doi:10.1006/bbrc.1999.1615. PMID 10544044.
• Mercer EA, Korhonen L, Skoglösa Y, et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways". EMBO J. 19 (14): 3597–607. doi:10.1093/emboj/19.14.3597. PMC 313967. PMID 10899114.
• Sanna MG, da Silva Correia J, Ducrey O, et al. (2002). "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition". Mol. Cell. Biol. 22 (6): 1754–66. doi:10.1128/MCB.22.6.1754-1766.2002. PMC 135597. PMID 11865055.
• Akutsu T, Nishio H, Sumino K, et al. (2002). "Molecular genetics of spinal muscular atrophy: contribution of the NAIP gene to clinical severity". Kobe Journal of Medical Sciences. 48 (1–2): 25–31. PMID 11912351.
• Xu M, Okada T, Sakai H, et al. (2002). "Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes". Biochim. Biophys. Acta. 1574 (1): 35–50. doi:10.1016/S0167-4781(01)00343-8. PMID 11955612.
• Notarbartolo M, Cervello M, Dusonchet L, D'Alessandro N (2002). "NAIP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells". Leuk. Res. 26 (9): 857–62. doi:10.1016/S0145-2126(02)00016-4. PMID 12127562.
• Lindholm D, Mercer EA, Yu LY, et al. (2002). "Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons". Biochim. Biophys. Acta. 1600 (1–2): 138–47. doi:10.1016/S1570-9639(02)00454-5. PMID 12445469.
• Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016.
• Davoodi J, Lin L, Kelly J, et al. (2004). "Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9". J. Biol. Chem. 279 (39): 40622–8. doi:10.1074/jbc.M405963200. PMID 15280366.
• Aubin D, Gagnon A, Grunder L, et al. (2004). "Adipogenic and antiapoptotic protein levels in human adipose stromal cells after weight loss". Obes. Res. 12 (8): 1231–4. doi:10.1038/oby.2004.156. PMID 15340105.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022.
• Romanish MT, Lock WM, van de Lagemaat LN, et al. (2007). "Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution". PLOS Genet. 3 (1): e10. doi:10.1371/journal.pgen.0030010. PMC 1781489. PMID 17222062.
• Maier JK, Balabanian S, Coffill CR, et al. (2007). "Distribution of neuronal apoptosis inhibitory protein in human tissues". J. Histochem. Cytochem. 55 (9): 911–23. doi:10.1369/jhc.6A7144.2007. PMID 17510375.

External links

• Neuronal+Apoptosis-Inhibitory+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q13075 (Baculoviral IAP repeat-containing protein 1) at the PDBe-KB.