Phosphatidic acid phosphatase 2c

PLPP2
Identifiers
Aliases	PLPP2, LPP2, PAP-2c, PAP2-g, PPAP2C, Phosphatidic acid phosphatase 2c, phospholipid phosphatase 2
External IDs	OMIM: 607126; MGI: 1354945; HomoloGene: 2752; GeneCards: PLPP2; OMA:PLPP2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	291,403 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,369,630 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; right uterine tube; ; mucosa of transverse colon; ; minor salivary glands; ; C1 segment; ; gallbladder; ; epithelium of bronchus; ; skin of abdomen; ; bronchial epithelial cell; ; skin of leg;
	Top expressed in
	ileum; ; duodenum; ; crypt of lieberkuhn of small intestine; ; pyloric antrum; ; intestinal villus; ; transitional epithelium of urinary bladder; ; jejunum; ; medullary collecting duct; ; left colon; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; protein binding; lipid phosphatase activity; hydrolase activity; sphingosine-1-phosphate phosphatase activity; phosphatidate phosphatase activity; phosphatase activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	phospholipid metabolic process; sphingolipid biosynthetic process; phospholipid dephosphorylation; signal transduction; protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	8612
	50784
	ENSG00000141934
	ENSMUSG00000052151
	O43688
	Q9DAX2
	NM_003712; NM_177526; NM_177543
	NM_015817; NM_001302389; NM_001302390; NM_001302442
	NP_003703; NP_803545; NP_808211
	NP_001289318; NP_001289319; NP_001289371; NP_056632
	Wikidata
View/Edit Human	View/Edit Mouse

Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141934 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052151 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID 9570154.
^ Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309. S2CID 31610109.
^ ^a ^b "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C".

Nanjundan M, Possmayer F (2003). "Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L1–23. doi:10.1152/ajplung.00029.2002. PMID 12471011.
Morris KE, Schang LM, Brindley DN (2006). "Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts". J. Biol. Chem. 281 (14): 9297–306. doi:10.1074/jbc.M511710200. PMID 16467304.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang N, Sundberg JP, Gridley T (2000). "Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile". Genesis. 27 (4): 137–40. doi:10.1002/1526-968X(200008)27:4<137::AID-GENE10>3.0.CO;2-4. PMID 10992322. S2CID 24643785.
Roberts R, Sciorra VA, Morris AJ (1998). "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform". J. Biol. Chem. 273 (34): 22059–67. doi:10.1074/jbc.273.34.22059. PMID 9705349.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141934 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052151 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9570154-5] Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID 9570154.

[pmid9607309-6] Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309. S2CID 31610109.

[entrez-7] "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C".

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References

Further reading