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Dentin phosphoprotein

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Dentin phosphoprotein, or phosphophoryn, is one of three proteins formed from dentin sialophosphoprotein and is important in the regulation of mineralization of dentin, [1] one of the main constituent materials of teeth (see dentinogenesis).

Phosphophoryn is the most acidic protein ever discovered and has an isoelectric point of 1. This extreme acidity is achieved by its amino acid sequence. Many portions of its chain are repeating −D−S−S− (aspartic acid-serine-serine) sequences. In protein chemistry, net acidity equates to negative charge. Being highly negative, dentin phosphoprotein is able to attract large amounts of calcium. In vitro studies also indicate phosphophoryn can initiate hydroxyapatite formation.[2]

References

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  1. ^ Cohen, Stephen, and Kenneth M. Hargreaves, eds. Pathways of the Pulp. 9th ed. St. Louis, MO: Mosby Elsevier, 2006. Print.
  2. ^ Nanci, Antonio. Ten Cate's Oral Histology: Development, Structure, and Function. 7th ed. St. Louis, MO: Mosby Elsevier, 2008. Print.