Hydrocholeretic

Hydrocholeretics are substances that increase the volume of secretion of bile from the liver without increasing the amount of solids secreted.^[1] Some substances can result in decreased solid production, possibly due to circulatory effects.^[2]

Cyclobutyrol is a compound commonly used as a hydrocholeretic. Its effects in rats include a dose-dependent increase in bile flow, sodium, potassium, chloride and bicarbonate outputs and reduced bile acid concentrations.^[3]

References

^ Textbook of Biochemistry and Human Biology, by G. P. Talwar, Talwar & Srivastava (eds.), L. M. Srivastava, p.610.
^ Brauer, R. W.; Pessotti, R. L. (1952). "The Effect of Choleretic and of Hydrocholeretic Agents on Bile Flow and Bile Solids in the Isolated Perfused Liver". Science. 115 (2980): 142–143. Bibcode:1952Sci...115..142B. doi:10.1126/science.115.2980.142. PMID 14913193.
^ Monte, MJ (1990). "Choleretic mechanism and effects of cyclobutyrol in the rat: dose-response relationship". Biomed Biochim Acta. 49 (1): 83–90. PMID 2360911.

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[1] Textbook of Biochemistry and Human Biology, by G. P. Talwar, Talwar & Srivastava (eds.), L. M. Srivastava, p.610.

[2] Brauer, R. W.; Pessotti, R. L. (1952). "The Effect of Choleretic and of Hydrocholeretic Agents on Bile Flow and Bile Solids in the Isolated Perfused Liver". Science. 115 (2980): 142–143. Bibcode:1952Sci...115..142B. doi:10.1126/science.115.2980.142. PMID 14913193.

[3] Monte, MJ (1990). "Choleretic mechanism and effects of cyclobutyrol in the rat: dose-response relationship". Biomed Biochim Acta. 49 (1): 83–90. PMID 2360911.

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See also

References