Nitrofuran
Nitrofurans are a class of drugs typically used as antibiotics or antimicrobials.[1] The defining structural component is a furan ring with a nitro group.[2]
Drugs
[edit]Members of this class of drugs include:
- Antibacterials (antibiotics)
- Difurazone (also known as Nitrovin) — an antibacterial growth promoter used in animal feeds
- Furazolidone
- Nifurfoline
- Nifuroxazide
- Nifurquinazol
- Nifurtoinol
- Nifurzide
- Nitrofural (also known as nitrofurazone)
- Nitrofurantoin — a drug used to treat urinary tract infections[3]
- Ranbezolid — technically an oxazolidinone antibiotic bearing a nitrofuran group
- Antimicrobials
- Furaltadone — an antiprotozoal
- Furazidine — an antibacterial and antiprotozoal
- Furaginum — an antibacterial
- Furylfuramide — a formerly used food preservative
- Nifuratel — an antiprotozoal and antifungal
- Nifurtimox — an antiprotozoal
- FANFT, a potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.
Regulation
[edit]The European Union has banned the use of Nitrofurans in food-producing animals. In the 2000s, a number of meat imports were destroyed after nitrofurans were found, including chicken imported from Portugal,[4] and chicken imported from Thailand and Brazil.[5]
References
[edit]- ^ Chu, Pak-Sin; Lopez, Mayda I; Abraham, Ann; El Said, Kathleen R; Plakas, Steven M (2008). "Residue Depletion of Nitrofuran Drugs and Their Tissue-Bound Metabolites in Channel Catfish (Ictalurus punctatus) after Oral Dosing". Journal of Agricultural and Food Chemistry. 56 (17): 8030–8034. doi:10.1021/jf801398p. PMID 18698789.
- ^ Vass, M; Hruska, K; Franek, M (2008). "Nitrofuran antibiotics: a review on the application, prohibition and residual analysis". Veterinarni Medicina. 53: 469–500. doi:10.17221/1979-VETMED.
- ^ Huttner, Angela; Verhaegh, Els M; Harbarth, Stephan; Muller, Anouk E; Theuretzbacher, Ursula; Mouton, Johan W (2015). "Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials". Journal of Antimicrobial Chemotherapy. 70 (9): 2456–2464. doi:10.1093/jac/dkv147. PMID 26066581.
- ^ "UK Food Law News (03-18)". www.reading.ac.uk.
- ^ "UK Food Law News (02-35)". www.reading.ac.uk.
External links
[edit]- Nitrofurans at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
