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Albendazole monooxygenase

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Albendazole monooxygenase
Identifiers
EC no.1.14.13.32
CAS no.101299-59-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an albendazole monooxygenase (EC 1.14.13.32) is an enzyme that catalyzes the chemical reaction

albendazole + NADPH + H+ + O2 albendazole S-oxide + NADP+ + H2O

The four substrates of this enzyme are albendazole, NADPH, H+, and O2, whereas its three products are albendazole S-oxide, NADP+, and H2O.

This enzyme is coded by the gene for CYP3A4[1][2] and belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor. The systematic name of this enzyme class is albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming). Other names in common use include albendazole oxidase, and albendazole sulfoxidase. It employs one cofactor, FAD.

References

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  1. ^ "Showing Protein Cytochrome P450 3A4 (HMDBP01018)". Human Metabolome Database. Retrieved 2017-08-05.
  2. ^ Enzyme 1.14.13.32 at KEGG
  • Fargetton X, Galtier P, Delatour P (1986). "Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes". Vet. Res. Commun. 10 (4): 317–324. doi:10.1007/BF02213995. PMID 3739217.