Ampyzine
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| Formula | C6H9N3 |
| Molar mass | 123.159 g·mol−1 |
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Ampyzine is a central nervous system stimulant.[1]
Synthesis[edit]
The classical method for synthesizing 2-aminopyrazines is illustrated by the synthesis of ampyzine. The condensation reaction between glyoxal and 2-aminomalonamide forms the pyrazine derivative (1). Acid-catalysed hydrolysis of the amide and decarboxylation gives 2-hydroxypyrazine (3). Halogenation with phosphorus pentachloride produces 2-chloropyrazine (4) which reacts with dimethylamine to yield ampyzine.[1][2]
References[edit]
- ^ a b Lednicer D, Mitscher LA (1980-05-13). The Organic Chemistry of Drug Synthesis. John Wiley & Sons. ISBN 9780471043928.
- ^ Emele Jane Frances, Wilson B Lutz, U.S. patent 3,249,503 (1966 to Warner Lambert Pharmaceutical).
External links[edit]
Media related to Ampyzine at Wikimedia Commons
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