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Anne Moscona

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Anne Moscona
Born
Chicago, Illinois, U.S.
Education
Scientific career
Institutions

Anne Moscona is an American virologist and pediatrician. Her research has identified cell entry mechanisms for enveloped respiratory viruses,[1] with applications to parainfluenza virus, Nipah virus, measles virus, and other viruses, and has applied this knowledge to the development of antiviral strategies to prevent infection by viruses including SARS-CoV-2.[2] Since 2016, she has served as the Sherie L. Morrison Professor of Microbiology & Immunology, Professor of Pediatrics, and Professor of Physiology & Cellular Biophysics at Columbia University Medical Center in New York City, where she also directs the Center for Host Pathogen Interaction.[3][4] In 2022, Moscona was elected as president of the American Society for Virology, the nation's leading virology research organization.[5]

Early life and education

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Moscona was born in Chicago, Illinois, where her parents, Aron Moscona[6][7] and Malka Moscona,[8] were Israeli-American developmental biologists at the University of Chicago.[9][10] Moscona received her BA in Molecular Biology & Biochemistry from Harvard University in 1978, and MD from Columbia University College of Physicians and Surgeons in 1982.[11]

Career

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Moscona completed her clinical and research training at Mount Sinai Health System in New York City. She was promoted to tenured professor in 2001 and served as chief of pediatric infectious diseases and vice chair for research until 2005. In 2005, she became professor of Pediatrics and of Microbiology and Immunology, vice chair for research of Pediatrics, and Chief of Pediatric Infectious Diseases at the Weill Cornell Medical Center,[12] before moving to Columbia in 2015 as a tri-departmental professor and center director. Moscona's research focuses on understanding how viruses enter human cells and how to use this knowledge to design better tools to prevent viral infection.[13] Her research program focuses on paramyxoviruses, a family of negative-sense RNA viruses that cause severe illness in humans,[14][15][16] and her group has developed new techniques to block viral infection through fusion inhibition,[17][18] most recently developing fusion inhibitory peptides for SARS-CoV-2.[19][20] She is frequently consulted as a  medical expert during viral outbreaks, including epidemic and pandemic influenza.[21][22][23] Her research has been featured in outlets including Nature, Science, the New England Journal of Medicine, the New York Times, CNN, NBC, ABC and The Hill.[24][25][26]

COVID-19

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On November 5, 2020, the New York Times reported that Moscona's research group had collaboratively developed “A nasal spray that blocks the absorption of the SARS-CoV-2 virus...” and that it had “...completely protected ferrets it was tested on, according to a small study...”[27] According to the article, the therapeutics are patent pending and awaiting market production.

Awards

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References

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  1. ^ "Moscona Lab". Department of Pediatrics. 1 October 2018. Retrieved 7 July 2022.
  2. ^ de Vries, Rory D.; Schmitz, Katharina S.; Bovier, Francesca T.; Predella, Camilla; Khao, Jonathan; Noack, Danny; Haagmans, Bart L.; Herfst, Sander; Stearns, Kyle N.; Drew-Bear, Jennifer; Biswas, Sudipta (26 March 2021). "Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets". Science. 371 (6536): 1379–1382. Bibcode:2021Sci...371.1379D. doi:10.1126/science.abf4896. ISSN 0036-8075. PMC 8011693. PMID 33597220.
  3. ^ "Anne Moscona, MD". Department of Pediatrics. 11 October 2018. Retrieved 7 July 2022.
  4. ^ "Center for Host-Pathogen Interaction". Department of Pediatrics. 21 July 2020. Retrieved 7 July 2022.
  5. ^ "Columbia Virologist-Pediatrician to Lead Nation's Leading Virus Research Organization". Columbia University Irving Medical Center. 14 June 2022. Retrieved 7 July 2022.
  6. ^ Mahowald, Anthony P. (2014). "Aron Moscona 1929-2009" (PDF). National Academy of Sciences.
  7. ^ McNeil, Donald G. Jr. (26 January 2009). "Aron Moscona, 87, Biologist Who Explored Embryonic Cells, Dies". The New York Times. ISSN 0362-4331. Retrieved 7 July 2022.
  8. ^ "Moscona, Malka : Photographic Archive : The University of Chicago". photoarchive.lib.uchicago.edu. Retrieved 7 July 2022.
  9. ^ "Aron A Moscona PhD 1921-2009". www.uchicagomedicine.org. Retrieved 7 July 2022.
  10. ^ "Aron A. Moscona, PhD, 1921-2009". news.uchicago.edu. 26 January 2009. Retrieved 8 July 2022.
  11. ^ "Anne Moscona, MD". Department of Pediatrics. 11 October 2018. Retrieved 7 July 2022.
  12. ^ Moscona, Anne (30 October 2009). "Invited Speaker". Idsa. {{cite journal}}: Cite journal requires |journal= (help)
  13. ^ "Moscona Lab". Department of Pediatrics. 1 October 2018. Retrieved 7 July 2022.
  14. ^ Moscona, Anne; Peluso (June 1991). "Fusion Properties of Cells Persistently Infected with Human Parainfluenza Virus Type 3: Participation of HemagglutininNeuraminidase in Membrane Fusion". Journal of Virology. 65 (6): 2773–2777. doi:10.1128/JVI.65.6.2773-2777.1991. PMC 240891. PMID 1851852.
  15. ^ Porotto, M.; Ferren, M.; Chen, Y.-W.; Siu, Y.; Makhsous, N.; Rima, B.; Briese, T.; Greninger, A. L.; Snoeck, H.-W.; Moscona, A. (25 June 2019). Schultz-Cherry, Stacey (ed.). "Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids". mBio. 10 (3). Carolyn Coyne, John Williams: e00723–19. doi:10.1128/mBio.00723-19. ISSN 2161-2129. PMC 6509192. PMID 31064833.
  16. ^ Greninger, Alexander L.; Rybkina, Ksenia; Lin, Michelle J.; Drew-Bear, Jennifer; Marcink, Tara C.; Shean, Ryan C.; Makhsous, Negar; Boeckh, Michael; Harder, Olivia; Bovier, Francesca; Burstein, Shana R. (1 December 2021). "Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence". The Journal of Clinical Investigation. 131 (23). doi:10.1172/JCI150506. ISSN 0021-9738. PMC 8631596. PMID 34609969.
  17. ^ Moscona, Anne (1 July 2005). "Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease". The Journal of Clinical Investigation. 115 (7): 1688–1698. doi:10.1172/JCI25669. ISSN 0021-9738. PMC 1159152. PMID 16007245.
  18. ^ Porotto, Matteo; Rockx, Barry; Yokoyama, Christine C.; Talekar, Aparna; DeVito, Ilaria; Palermo, Laura M.; Liu, Jie; Cortese, Riccardo; Lu, Min; Feldmann, Heinz; Pessi, Antonello (28 October 2010). "Inhibition of Nipah Virus Infection In Vivo: Targeting an Early Stage of Paramyxovirus Fusion Activation during Viral Entry". PLOS Pathogens. 6 (10): e1001168. doi:10.1371/journal.ppat.1001168. ISSN 1553-7374. PMC 2965769. PMID 21060819.
  19. ^ Outlaw, Victor K.; Bovier, Francesca T.; Mears, Megan C.; Cajimat, Maria N.; Zhu, Yun; Lin, Michelle J.; Addetia, Amin; Lieberman, Nicole A. P.; Peddu, Vikas; Xie, Xuping; Shi, Pei-Yong (27 October 2020). Schultz-Cherry, Stacey (ed.). "Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain". mBio. 11 (5): e01935–20. doi:10.1128/mBio.01935-20. ISSN 2161-2129. PMC 7587434. PMID 33082259.
  20. ^ de Vries, Rory D.; Schmitz, Katharina S.; Bovier, Francesca T.; Predella, Camilla; Khao, Jonathan; Noack, Danny; Haagmans, Bart L.; Herfst, Sander; Stearns, Kyle N.; Drew-Bear, Jennifer; Biswas, Sudipta (26 March 2021). "Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets". Science. 371 (6536): 1379–1382. Bibcode:2021Sci...371.1379D. doi:10.1126/science.abf4896. ISSN 0036-8075. PMC 8011693. PMID 33597220.
  21. ^ "CNN.com - Expert: Window exists to prepare for pandemic - Nov 1, 2005". www.cnn.com. Retrieved 7 July 2022.
  22. ^ McNeil, Donald G. Jr. (21 May 2009). "As Flu Suspicions Spread, Value of Test Is Weighed". The New York Times. ISSN 0362-4331. Retrieved 7 July 2022.
  23. ^ Moscona, Anne (22 December 2005). "Oseltamivir Resistance — Disabling Our Influenza Defenses". New England Journal of Medicine. 353 (25): 2633–2636. doi:10.1056/NEJMp058291. ISSN 0028-4793. PMID 16371626.
  24. ^ Folkman, Judah; Moscona, Anne (June 1978). "Role of cell shape in growth control". Nature. 273 (5661): 345–349. Bibcode:1978Natur.273..345F. doi:10.1038/273345a0. ISSN 1476-4687. PMID 661946. S2CID 4161255.
  25. ^ Moscona, Anne (29 September 2005). "Neuraminidase Inhibitors for Influenza". New England Journal of Medicine. 353 (13): 1363–1373. doi:10.1056/NEJMra050740. ISSN 0028-4793. PMID 16192481.
  26. ^ "New treatment may protect babies against dangerous respiratory virus, study shows". NBC News. 3 March 2022. Retrieved 7 July 2022.
  27. ^ McNeil, Donald G. Jr. (5 November 2020). "Nasal Spray Prevents Covid Infection in Ferrets, Study Finds". The New York Times. ISSN 0362-4331. Retrieved 8 July 2022.
  28. ^ "The Charles H. Revson Senior Fellowship in Biomedical Science | The Charles H. Revson Foundation". Retrieved 7 July 2022.
  29. ^ Foundation, PIDS. "Young Investigator Award – PIDS Foundation". pidsfoundation.org. Retrieved 7 July 2022.
  30. ^ "AWARDS FOR MEDICAL RESEARCH". The New York Times. 31 January 1982. ISSN 0362-4331. Retrieved 7 July 2022.
  31. ^ "The American Society for Clinical Investigation". Retrieved 7 July 2022.
  32. ^ "Investigators in the Pathogenesis of Infectious Disease". Burroughs Wellcome Fund. Retrieved 7 July 2022.
  33. ^ "American Academy of Microbiology". ASM.org. Retrieved 7 July 2022.
  34. ^ "About ASV". American Society for Virology. Retrieved 7 July 2022.
  35. ^ "Anne Moscona, MD | Scholars | Harrington Discovery Institute at University Hospitals". www.harringtondiscovery.org. Retrieved 7 July 2022.
  36. ^ "Public Affairs". American Society for Virology. Retrieved 7 July 2022.
  37. ^ "Columbia Virologist-Pediatrician to Lead Nation's Leading Virus Research Organization". Columbia University Irving Medical Center. 14 June 2022. Retrieved 7 July 2022.
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