Bavdegalutamide

Bavdegalutamide
Clinical data
Other names	ARV-110
Identifiers
	IUPAC name N-[4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindol-5-yl]piperazin-1-yl]methyl]piperidin-1-yl]pyridazine-3-carboxamide;
CAS Number	2222112-77-6;
PubChem CID	134414307;
DrugBank	DB19032;
ChemSpider	110415899;
UNII	H6NYM0V650;
KEGG	D12316;
ChEMBL	ChEMBL4862963;
Chemical and physical data
Formula	C41H43ClFN9O6
Molar mass	812.30 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC(CCC1NC(=O)C2=NN=C(C=C2)N3CCC(CC3)CN4CCN(CC4)C5=C(C=C6C(=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O)F)OC8=CC(=C(C=C8)C#N)Cl;
	InChI InChI=InChI=1S/C41H43ClFN9O6/c42-31-19-28(4-1-25(31)22-44)58-27-5-2-26(3-6-27)45-38(54)33-7-9-36(48-47-33)51-13-11-24(12-14-51)23-49-15-17-50(18-16-49)35-21-30-29(20-32(35)43)40(56)52(41(30)57)34-8-10-37(53)46-39(34)55/h1,4,7,9,19-21,24,26-27,34H,2-3,5-6,8,10-18,23H2,(H,45,54)(H,46,53,55); Key:CLCTZVRHDOAUGJ-UHFFFAOYSA-N;

Bavdegalutamide is an experimental proteolysis targeting chimera that functions as a androgen receptor degrader.^[1] It is being developed to treat metastatic castration-resistant prostate cancer.^[2]^[3]^[4]

References

^ "Bavdegalutamide". PubChem. U.S. National Library of Medicine. Retrieved 2024-10-31.
^ Shore ND, Shen J, Devitt ME, Lu H, Alicea J, Parameswaran J, et al. (June 2022). "Phase 1b study of bavdegalutamide, an androgen receptor PROTAC degrader, combined with abiraterone in patients with metastatic prostate cancer". Journal of Clinical Oncology. 40 (16_suppl): TPS5106–TPS5106. doi:10.1200/JCO.2022.40.16_suppl.TPS5106. ISSN 0732-183X.
^ "Bavdegalutamide - Arvinas". AdisInsight. Springer Nature Switzerland AG.
^ Jia X, Han X (February 2023). "Targeting androgen receptor degradation with PROTACs from bench to bedside". Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 158: 114112. doi:10.1016/j.biopha.2022.114112. PMID 36508999.

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