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Bone morphogenetic protein 3

From Wikipedia, the free encyclopedia

BMP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBMP3, BMP-3A, bone morphogenetic protein 3
External IDsOMIM: 112263; MGI: 88179; HomoloGene: 927; GeneCards: BMP3; OMA:BMP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001201

NM_173404
NM_001310677

RefSeq (protein)

NP_001192

NP_001297606
NP_775580

Location (UCSC)Chr 4: 81.03 – 81.06 MbChr 5: 99 – 99.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.[5]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, unlike other bone morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Cancer

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BMP3 is hypermethylated in many cases of colorectal cancer (CRC) and hence along with other hypermethylated genes, may be used as a biomarker to detect early stage CRC.[6][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152785Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029335Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
  6. ^ Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (June 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease. 18 (6): 549–61. doi:10.1111/codi.13336. PMID 26998585. S2CID 25724654.
  7. ^ Kormi SM, Ardehkhani S, Kerachian MA (November 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer. 6 (2): 63–68. doi:10.2217/crc-2017-0007.
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Further reading

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