CDGSH iron sulfur domain

CDGSH iron sulfur domain 1
CDGSH iron sulfur domain 1
Identifiers
Symbol	CISD1
Alt. symbols	C10orf70, ZCD1
NCBI gene	55847
HGNC	30880
PDB	2QH7
RefSeq	NM_018464
UniProt	Q9NZ45
Other data
Locus	Chr. 10 q21.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CDGSH iron sulfur domain
CDGSH iron sulfur domain
	Crystallographic structure (PDB: 2QH7) of the CDGSH-type domain 1 dimer (green and cyan cartoon) complexed with iron (brown) and sulfur (yellow) Fe-S clusters.
Identifiers
Symbol	CDGSH
Pfam	PF10660
InterPro	IPR019610
Membranome	212
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CDGSH iron sulfur domain 2

Identifiers

Symbol

CISD2

Alt. symbols

ZCD2

Other data

Chr. 4 q24

Search for
Structures	Swiss-model
Domains	InterPro

CDGSH iron sulfur domain 3
Identifiers
Symbol	CISD3
NCBI gene	284106
HGNC	27578
Other data
Locus	Chr. 17 q12

The CDGSH iron sulfur domain are a group of iron-sulfur (2Fe-2S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].

The CDGSH iron sulfur domain 1 protein (also referred to as mitoNEET) is an integral membrane protein located in the outer mitochondrial membrane and whose function may be to transport iron into the mitochondria.^[1] Iron in turn is essential for the function of several mitochondrial enzymes.

The antidiabetic drug pioglitazone, in addition to binding to the nuclear receptor PPAR, also has been shown to bind mitoNEET with approximately equal affinity.^[2]

References

^ Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA (2007). "MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone". Proc. Natl. Acad. Sci. U.S.A. 104 (36): 14342–7. Bibcode:2007PNAS..10414342P. doi:10.1073/pnas.0707189104. PMC 1963346. PMID 17766440.
^ Colca JR, McDonald WG, Waldon DJ, Leone JW, Lull JM, Bannow CA, Lund ET, Mathews WR (2004). "Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe". Am. J. Physiol. Endocrinol. Metab. 286 (2): E252–60. doi:10.1152/ajpendo.00424.2003. PMID 14570702.

External links

ZCD1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[pmid17766440-1] Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA (2007). "MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone". Proc. Natl. Acad. Sci. U.S.A. 104 (36): 14342–7. Bibcode:2007PNAS..10414342P. doi:10.1073/pnas.0707189104. PMC 1963346. PMID 17766440.

[pmid14570702-2] Colca JR, McDonald WG, Waldon DJ, Leone JW, Lull JM, Bannow CA, Lund ET, Mathews WR (2004). "Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe". Am. J. Physiol. Endocrinol. Metab. 286 (2): E252–60. doi:10.1152/ajpendo.00424.2003. PMID 14570702.

[1]

[2]