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Chlordecone reductase

From Wikipedia, the free encyclopedia
chlordecone reductase
Identifiers
EC no.1.1.1.225
CAS no.102484-73-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction

chlordecone alcohol + NADP+ chlordecone + NADPH + H+

Thus, the two substrates of this enzyme are chlordecone alcohol and NADP+, whereas its 3 products are chlordecone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FVL.

References

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  • Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. Biol. Chem. 261 (27): 12624–7. doi:10.1016/S0021-9258(18)67136-4. PMID 2427522.