Corticosteroid receptor
The corticosteroid receptors are receptors for corticosteroids.[1] Corticosteroid receptors mediate the target organ response to the major products of the adrenal cortex, glucocorticoids (principally cortisol in man), and mineralocorticoids (principally aldosterone). They are members of the intracellular receptor superfamily which is highly evolutionarily conserved, and includes receptors for thyroid hormones, vitamin D, sex steroids, and retinoids.[2] They include the following two nuclear receptors:[1][3][4]
- Glucocorticoid receptor (type I) – glucocorticoids like cortisol
- Mineralocorticoid receptor (type I) – mineralocorticoids like aldosterone
There are also membrane corticosteroid receptors, including the membrane glucocorticoid receptors and the membrane mineralocorticoid receptors, which are not well-characterized at present.[5][6][7]
References[edit]
- ^ a b Scott T. Brady; George J. Siegel; Robert Wayne Albers; Donald Lowell Price (2012). Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology. Academic Press. pp. 522–. ISBN 978-0-12-374947-5.
- ^ Walker, Brian R.; Stewart, Paul M.; Edwards, Christopher R.W. (1997), "Enzyme Modulation of Access to Corticosteroid Receptors", Molecular and Cellular Endocrinology, Elsevier, pp. 297–310, doi:10.1016/s1569-2582(97)80038-4, retrieved 2024-07-15
- ^ Eugenia Wang; D. Stephen Snyder (13 August 1998). Handbook of the Aging Brain. Academic Press. pp. 22–. ISBN 978-0-08-053322-3.
- ^ Hormones, Brain and Behavior, Five-Volume Set. Academic Press. 18 June 2002. pp. 267–. ISBN 978-0-08-053415-2.
- ^ Groeneweg FL, Karst H, de Kloet ER, Joëls M (2012). "Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling". Mol. Cell. Endocrinol. 350 (2): 299–309. doi:10.1016/j.mce.2011.06.020. PMID 21736918. S2CID 23048944.
- ^ Tasker JG, Di S, Malcher-Lopes R (2006). "Minireview: rapid glucocorticoid signaling via membrane-associated receptors". Endocrinology. 147 (12): 5549–56. doi:10.1210/en.2006-0981. PMC 3280589. PMID 16946006.
- ^ Dooley R, Harvey BJ, Thomas W (2012). "Non-genomic actions of aldosterone: from receptors and signals to membrane targets". Mol. Cell. Endocrinol. 350 (2): 223–34. doi:10.1016/j.mce.2011.07.019. PMID 21801805. S2CID 24630510.