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Innovative Vector Control Consortium

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The Innovative Vector Control Consortium (IVCC) is a not-for-profit, product development partnership (PDP)[1][2] designed to facilitate the development and delivery of new and improved vector control[3] tools to prevent malaria and other neglected tropical diseases. Their mission is to save lives, protect health, and increase prosperity in areas where disease transmitted by insects is endemic.

Formation and Organisational Structure

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The Innovative Vector Control Consortium (IVCC) is a not-for-profit public-private partnership that was established in 2005.[4] IVCC is registered as a charity in the UK.[1] IVCC was founded in 2005, through a grant to the Liverpool School of Tropical Medicine (LSTM), by the Bill and Melinda Gates Foundation.[4] IVCC was founded by LSTM Director and Professor Janet Hemingway.[5]

Nick Hamon is the Chief Executive Officer of IVCC.[6] IVCC is headquartered in Liverpool, UK,[7] but also has a registered office and staff in Washington, D.C., USA, as well as staff based in several other countries. The strategy and scope of IVCC is directed by its core team under governance of the Board of Trustees who represent a wide range of expertise.[8]

Strategy

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The IVCC vision is to save lives, protect health and increase prosperity in areas where disease transmitted by insects is endemic.[9] The IVCC mission is to do this by building partnerships that create innovative solutions to prevent the transmission of insect-borne disease.[10] IVCC facilitates the development and delivery of novel and improved vector control tools[11][12][13][14][15] and solutions to combat the rapidly growing problem of insecticide resistance.[16]

The IVCC strategic plan is focused on three key pillars: developing, delivering, and enabling. IVCC works with multiple stakeholders[17] to develop and deliver novel public health vector control insecticides and tools to end-users to support the implementation of robust insecticide resistance management plans.[18]  This will enable national malaria control programs [19] to access a strong portfolio of new vector control solutions[20] developed by stringent target product profiles.

Although primarily focused on malaria,[21] IVCC recognises that new tools and products can be effective against a wide range of other vector-borne diseases.[22]

Funding

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IVCC was originally funded by the Bill and Melinda Gates Foundation with a grant of $50.7 million over five years,[23] the Bill and Melinda Gates Foundation continues to fund IVCC today.[24] IVCC is also principally funded by UKaid,[25] USAID,[26] Unitaid,[27] The Swiss Agency for Development and Cooperation,[28] The Global Fund[29] and the Australian Government.[30]

Partners

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IVCC has active partnerships with agrochemical companies, non-governmental organisations, governmental organisations, and academia.  IVCC's primary industrial partners include BASF,[12] Bayer,[14][31] Mitsui,[32] Sumitomo[18] and Syngenta.[15][33] Additional IVCC partners include Abt Associates,[34] Imperial College London,[35] The London School of Hygiene & Tropical Medicine,[36] Liverpool School of Tropical Medicine,[37] PATH,[38] PMI,[34] The Global Fund,[39] Tagros, Vestergaard Fransden[40][full citation needed] and Westham.[41]

Malaria Eradication

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IVCC fully supports the Bill and Melinda Gates Foundation's report 'From Aspiration to Action' which sets out a comprehensive and achievable strategy for malaria eradication by 2040.[42] ZERO by 40 [43] is an initiative that works side by side with other malaria-fighting organisations toward the goal of ending the disease for good by the year 2040.[44] For its part, ZERO by 40 focuses on the prevention of malaria through vector control. Founding partners of the initiative include IVCC and key global Crop Protection companies BASF, Bayer, Mitsui, Sumitomo , and  Syngenta, in conjunction with the Bill and Melinda Gates Foundation.[45] ZERO by 40 is a collaborative effort to manage and optimise current resources and innovate new vector control tools to help eradicate malaria.[46][47][48]

Successes

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IVCC has made great strides toward achieving its mission and has recorded many key accomplishments to date. A sample of these accomplishments include:

  • Evaluation of over 4.5 million compounds for potential use as public health insecticides leading to six classes of novel active ingredients identified for possible development.[49]
  • Forged partnerships to establish African trial sites and new insectaries to provide industry-standard testing.[50]
  • Developed a diagnostic system for malarial insecticide resistance detection and implemented it within disease control programs in Africa.[51]
  • Launched two new long-lasting indoor residual spray formulations to expand the range of vector control tools for challenging malaria insecticide resistance.[52]
  • Delivery of disease data management system software to national control programs.[53]
  • Launched insecticide quantification kits to monitor spray program implementation.[54]
  • Facilitated the first African vector control field trial site to achieve good laboratory practice (GLP) certification. Six other African vector control field trial site facilities are expected to achieve GLP certification by the end of 2018.[55]
  • Collaborated with BASF to develop the first new class of public health insecticide for malaria prevention in over 30 years. Interceptor® G2 is a LLIN that received an interim recommendation from WHO in June 2017.[56]
  • Led a US$65.1 million initiative to support countries in obtaining new and effective insecticides at lower prices to spray walls in homes and fight growing insecticide resistance.[57]

References

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  1. ^ a b "Charity overview". apps.charitycommission.gov.uk. Retrieved 2019-03-19.
  2. ^ "IVCC and LSTM Connections – The Liverpool Insect Testing Establishment". www.lite-testing-facility.com. Archived from the original on 2019-03-12. Retrieved 2019-03-19.
  3. ^ Kleinschmidt, Immo; Rowland, Mark; Mzilahowa, Themba; Nchama, Gloria Nseng; Aragon, Cynthia; Yellott, Lee; Gomes, Irina Roncon; Matias, Abrahan; Baltazar, Giovanna (2011-04-29). "How Much Does Malaria Vector Control Quality Matter: The Epidemiological Impact of Holed Nets and Inadequate Indoor Residual Spraying". PLOS ONE. 6 (4): e19205. Bibcode:2011PLoSO...619205R. doi:10.1371/journal.pone.0019205. ISSN 1932-6203. PMC 3084796. PMID 21559436.
  4. ^ a b "IVCC Develops New Public Health Insecticides". Bill & Melinda Gates Foundation. Retrieved 2019-03-19.
  5. ^ Echo, Liverpool (2010-11-22). "Bill Gates donates £31m to Liverpool School of Tropical Medicine for malaria research". liverpoolecho. Retrieved 2019-03-19.
  6. ^ "Dr Nick Hamon to succeed Professor Janet Hemingway as CEO of IVCC". LSTM. Retrieved 2019-03-19.
  7. ^ "IVCC – Overview (free company information from Companies House)". beta.companieshouse.gov.uk. Retrieved 2019-03-19.
  8. ^ "Annual reports | IVCC". www.ivcc.com. Retrieved 2019-03-19.
  9. ^ "WHO | World malaria report 2018". WHO. Archived from the original on November 21, 2018. Retrieved 2019-03-19.
  10. ^ "Vector Control Innovation" (PDF).
  11. ^ "WHO | Vector control". WHO. Archived from the original on August 22, 2017. Retrieved 2019-03-19.
  12. ^ a b "BASF introduces first new class of public health insecticide for malaria prevention in more than 30 years". www.basf.com. Retrieved 2019-03-19.
  13. ^ "BASF and IVCC announce cooperation for next generation products for Malaria Control | malaria.lshtm.ac.uk". malaria.lshtm.ac.uk. Retrieved 2019-03-19.[permanent dead link]
  14. ^ a b "Bayer announces WHO pre-qualification for Fludora™ Fusion to combat malaria". www.vectorcontrol.bayer.com. Archived from the original on 2020-08-08. Retrieved 2019-03-19.
  15. ^ a b "Syngenta announces a new malaria insecticide entering early development phase". www.syngenta.com. Retrieved 2019-03-19.
  16. ^ "WHO | Insecticide resistance". WHO. Archived from the original on October 11, 2014. Retrieved 2019-03-19.
  17. ^ "World Malaria Summit 2018". www.vectorcontrol.bayer.com. Retrieved 2019-03-19.[permanent dead link]
  18. ^ a b "A new insecticide to be used to fight malaria". Unitaid. Retrieved 2019-03-19.
  19. ^ "WHO | About the WHO Global Malaria Programme". WHO. Archived from the original on March 17, 2010. Retrieved 2019-03-19.
  20. ^ "New vector-control response seen as game-changer". www.who.int. Retrieved 2019-03-19.
  21. ^ Desowitz, Robert S. (1993). The Malaria Capers: More Tales of Parasites and People, Research and Reality. W.W. Norton. ISBN 0-393-31008-6.
  22. ^ "Vector Control". LSTM. Retrieved 2019-03-19.
  23. ^ "IVCC Develops New Public Health Insecticides". Bill & Melinda Gates Foundation. Retrieved 2019-03-20.
  24. ^ "Awarded Grants". Bill & Melinda Gates Foundation. Retrieved 2019-03-20.
  25. ^ "UKAID grant supports next generation anti-malaria insecticides development | IVCC". www.ivcc.com. Archived from the original on 2015-10-07. Retrieved 2019-03-20.
  26. ^ "Research and Innovation". www.usaid.gov. 2018-04-26. Archived from the original on 2019-02-08. Retrieved 2019-03-20.
  27. ^ "Unitaid | Annual report". Unitaid | Annual report. Retrieved 2019-03-20.
  28. ^ "Funders | IVCC". www.ivcc.com. Retrieved 2019-03-20.
  29. ^ "What's new about the New Nets Project?". Retrieved 2019-03-20.
  30. ^ "IVCC | Indo-Pacific Centre for Health Security". indopacifichealthsecurity.dfat.gov.au. Archived from the original on 2019-03-09. Retrieved 2019-03-20.
  31. ^ "World Malaria Summit 2018". www.vectorcontrol.bayer.com. Retrieved 2019-03-19.[permanent dead link]
  32. ^ "Malaria No More | Post event". Malaria No More. Archived from the original on 2019-03-09. Retrieved 2019-03-19.
  33. ^ "World Malaria Summit 2018". www.vectorcontrol.bayer.com. Retrieved 2019-03-19.[permanent dead link]
  34. ^ a b "PMI AIRS Partners with IVCC and UNITAID to Combat Malaria with New Insecticides". Abt Associates. 3 February 2016. Retrieved 2019-03-19.
  35. ^ "Insecticide resistance". Imperial College London. Retrieved 2019-03-19.
  36. ^ "Novel mosquito net to combat insecticide resistance recommended by World Health Organization". LSHTM. Retrieved 2019-03-19.
  37. ^ "IVCC – Sustainable Capacity for Africa Vector Control Research and Product Development". LSTM. Retrieved 2019-03-19.[permanent dead link]
  38. ^ UNITAID (2017-05-04). "Saving lives with new insecticides to fight malaria — a photo story". Medium. Retrieved 2019-03-19.
  39. ^ "The New Nets Project in partnership with the Global Fund". Unitaid. Retrieved 2019-03-19.
  40. ^ "Insecticides: Researchers probe creative ways to kill mosquitoes | Financial Times". www.ft.com. Retrieved 2023-08-15.
  41. ^ "Westham – About". westhamco.com. Retrieved 2019-03-19.
  42. ^ "Malaria No More | From Aspiration to Action". Malaria No More. Retrieved 2019-03-20.
  43. ^ "ZERO by 40 – Eradicate Malaria by the Year 2040". Zero by 40. Retrieved 2019-03-20.
  44. ^ "Our goal: A world free of malaria by 2040". www.basf.com. Retrieved 2019-03-20.
  45. ^ "Bill Gates Is Pouring Another $1 Billion Into the Fight Against Malaria". Fortune. Retrieved 2019-03-20.
  46. ^ "BASF joins". Sustainable Brands. 2018-04-23. Retrieved 2019-03-20.
  47. ^ "Zero by 40 Commitments" (PDF).
  48. ^ "Bayer commits to provide innovative vector control solutions to help eradicate malaria by 2040 – Bayer News". media.bayer.com. Archived from the original on 2019-02-07. Retrieved 2019-03-20.
  49. ^ "Ghana PPP pilots breakthrough insecticide to fight mosquito resistance". Devex. 2018-07-10. Retrieved 2019-03-20.
  50. ^ "Trial sites and insectaries | IVCC". www.ivcc.com. Retrieved 2019-03-20.
  51. ^ Hemingway Janet (2014-06-19). "The role of vector control in stopping the transmission of malaria: threats and opportunities". Philosophical Transactions of the Royal Society B: Biological Sciences. 369 (1645): 20130431. doi:10.1098/rstb.2013.0431. PMC 4024224. PMID 24821917.
  52. ^ "Achievements | IVCC". www.ivcc.com. Retrieved 2019-03-20.
  53. ^ Liverpool School of Tropical Medicine (2015-03-12), The Disease Data Management System, retrieved 2019-03-20
  54. ^ "Insecticide Quantification Kit (IQK) | IVCC". www.ivcc.com. Archived from the original on 2019-03-18. Retrieved 2019-03-20.
  55. ^ "PAMVERC-KCMUCo Test Facility, Moshi, Tanzania (collaborator with LSHTM)". Innovation to Impact. Retrieved 2019-03-20.
  56. ^ "Our goal: A world free of malaria by 2040". www.basf.com. Retrieved 2019-03-20.
  57. ^ "SumiShield® 50WG joins NgenIRS | Sumitomo Chemical". sumivector.com. 18 December 2017. Archived from the original on 2018-03-18. Retrieved 2019-03-20.
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