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Isomorph (gene)

From Wikipedia, the free encyclopedia

In Muller's classification, an isomorph is described as a gene mutation that expresses a nonsense point mutant, with expression identical to the original allele.

Therefore, in respect to the relationships between the original and mutated genes, it is difficult to ascertain the effects of dominanceness and/or recessiveness.[1][2] [3]

Muller's classification of mutant alleles
Category Alternative function
Wild type Referent gene expression, normal expression of parent allele
Amorph Dysfunctional, with null expression
Hypomorph Reduced or partially reduced gene activity
Hypermorph Increased or partially increased parent gene activity
Neomorph Novel function, compared to the new property
Antimorph Interfering with gene activity
Isomorph Expression identical to the original (parent) allele, mostly resulting from silent point mutations

See also

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References

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  1. ^ Lawrence E., ed. (1999). Henderson's Dictionary of biological terms. London: Longman Group Ltd. ISBN 0-582-22708-9.
  2. ^ Rieger R. Michaelis A.; Green M. M. (1976). Glossary of genetics and cytogenetics: Classical and molecular. Berlin - Heidelberg - New York: Springer-Verlag. ISBN 3-540-07668-9.
  3. ^ "Archived copy" (PDF). Archived from the original (PDF) on 2019-08-19. Retrieved 2017-01-27.{{cite web}}: CS1 maint: archived copy as title (link)