Laughter-induced syncope

Laughter-induced syncope is an unusual but recognized form of situational syncope (fainting) likely to have a similar pathophysiological origin to tussive syncope. One reported case occurred while a patient was watching the television show Seinfeld, and was given the name Seinfeld syncope.^[1]

There are few case reports of this syndrome in the literature. Patients, as in this case, might present initially to the emergency department, and laughter should be considered among the numerous differentials for syncope.

Laughter-induced syncope should not be confused with cataplexy, a sudden loss of muscle tone triggered by strong emotions, particularly laughter. Unlike syncope, there is no loss of consciousness in cataplexy, which affects 65-75% of patients with narcolepsy.^[2]

To date there have been few cases of laughter-induced syncope documented in medical literature.^[3]

References

^ Cox SV, Eisenhauer AC, Hreib K (October 1997). "Seinfeld syncope". Catheterization and Cardiovascular Diagnosis. 42 (2): 242. doi:10.1002/(SICI)1097-0304(199710)42:2<242::AID-CCD41>3.0.CO;2-M. PMID 9328725.
^ Khan, Z; Trotti, LM (July 2015). "Central Disorders of Hypersomnolence: Focus on the Narcolepsies and Idiopathic Hypersomnia". Chest. 148 (1): 262–273. doi:10.1378/chest.14-1304. PMC 4694150. PMID 26149554.
^ Bloomfield and Jazrawi; Jazrawi, S (2005). "Shear Hilarity Leading to Laugh Syncope in a Healthy Man". Journal of the American Medical Association. 293 (23): 2863–2864. doi:10.1001/jama.293.23.2863-b. PMID 15956630.

S. Braga; R. Manni; R. Pedretti (August 2005). "Laughter-induced syncope". The Lancet. 366 (9483): 426. doi:10.1016/S0140-6736(05)67027-4. PMID 16054945. S2CID 29552987.
Matthew J Bragg (2006). "Fall about laughing: A case of laughter syncope". Emergency Medicine Australasia. 18 (5–6): 518–519. doi:10.1111/j.1742-6723.2006.00877.x. PMID 17083645. S2CID 30648068.
Roland D. Thijs, Wouter Wieling, Horacio Kaufmann, and Gert van Dijk1 (2004-10-11). "Defining and classifying syncope". Clinical Autonomic Research. 14 (1). Steinkopff: i4–i8. doi:10.1007/s10286-004-1002-4. PMID 15480929. S2CID 24259326.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
C. Mathias; K. Deguchi; I. Schatz (2001). "Observations on recurrent syncope and presyncope in 641 patients". The Lancet. 357 (9253): 348–353. doi:10.1016/S0140-6736(00)03642-4. PMID 11210997. S2CID 11341449.
Lois E. Krahn; James F. Lymp; Wendy R. Moore; Nancy Slocumb; Michael H. Silber (2003-06-05). "Characterizing the Emotions That Trigger Cataplexy". Journal of Neuropsychiatry and Clinical Neurosciences. 17 (1). American Psychiatric Press, Inc.: 45–50. doi:10.1176/jnp.17.1.45. PMID 15746482.
A. KENNEDY (2004). "Non-epileptic causes of loss of consciousness". Medicine. 32 (9): 15–17. doi:10.1383/medc.32.9.15.49910.

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[pmid9328725-1] Cox SV, Eisenhauer AC, Hreib K (October 1997). "Seinfeld syncope". Catheterization and Cardiovascular Diagnosis. 42 (2): 242. doi:10.1002/(SICI)1097-0304(199710)42:2<242::AID-CCD41>3.0.CO;2-M. PMID 9328725.

[2] Khan, Z; Trotti, LM (July 2015). "Central Disorders of Hypersomnolence: Focus on the Narcolepsies and Idiopathic Hypersomnia". Chest. 148 (1): 262–273. doi:10.1378/chest.14-1304. PMC 4694150. PMID 26149554.

[3] Bloomfield and Jazrawi; Jazrawi, S (2005). "Shear Hilarity Leading to Laugh Syncope in a Healthy Man". Journal of the American Medical Association. 293 (23): 2863–2864. doi:10.1001/jama.293.23.2863-b. PMID 15956630.

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References

Further reading