Mir-187 microRNA precursor family
| mir-187 | |
|---|---|
| Identifiers | |
| Symbol | mir-187 |
| Rfam | RF00674 |
| miRBase family | 8 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-187 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-187 has been found to be expressed at higher levels in ovarian cancers compared with benign tumours.[1] It is known to target DAB2 (disabled homolog-2), a protein encoded by the DAB2 gene, with miR-187's target site at the 3'UTR of the DAB2 gene. DAB2 has been seen to play roles in both cell proliferation and tumour progression, and initial expression of miR-187 in cancer cells promotes cell proliferation. However, overexpression suppresses DAB2 and inhibits epithelial to mesenchymal cell transition. High miR-187 levels have accordingly been associated with higher survival rates in ovarian cancer patients.[1]
See also
[edit]Further reading
[edit]- ^ a b Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, Hsueh S, et al. (2012). "Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2". Oncogene. 31 (6): 764–75. doi:10.1038/onc.2011.269. PMID 21725366.
- ^ Shaoqing, Y.; Ruxin, Z.; Guojun, L.; Zhiqiang, Y.; Hua, H.; Shudong, Y.; Jie, Z. (2011). "Microarray analysis of differentially expressed microRNAs in allergic rhinitis". American Journal of Rhinology and Allergy. 25 (6): e242–e246. doi:10.2500/ajra.2011.25.3682. PMID 22185732. S2CID 45915750.
- ^ Liu, H.; Zhu, L.; Liu, B.; Yang, L.; Meng, X.; Zhang, W.; Ma, Y.; Xiao, H. (2012). "Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer". Cancer Letters. 316 (2): 196–203. doi:10.1016/j.canlet.2011.10.034. PMID 22169097.
- ^ Godwin, J. G.; Ge, X.; Stephan, K.; Jurisch, A.; Tullius, S. G.; Iacomini, J. (2010). "Identification of a microRNA signature of renal ischemia reperfusion injury". Proceedings of the National Academy of Sciences. 107 (32): 14339–14344. Bibcode:2010PNAS..10714339G. doi:10.1073/pnas.0912701107. PMC 2922548. PMID 20651252.
- ^ Nicoloso, M. S.; Sun, H.; Spizzo, R.; Kim, H.; Wickramasinghe, P.; Shimizu, M.; Wojcik, S. E.; Ferdin, J.; Kunej, T.; Xiao, L.; Manoukian, S.; Secreto, G.; Ravagnani, F.; Wang, X.; Radice, P.; Croce, C. M.; Davuluri, R. V.; Calin, G. A. (2010). "Single-Nucleotide Polymorphisms Inside MicroRNA Target Sites Influence Tumor Susceptibility". Cancer Research. 70 (7): 2789–2798. doi:10.1158/0008-5472.CAN-09-3541. PMC 2853025. PMID 20332227.
- ^ Xu, G.; Zhang, Y.; Jia, H.; Li, J.; Liu, X.; Engelhardt, J. F.; Wang, Y. (2009). "Cloning and identification of microRNAs in bovine alveolar macrophages". Molecular and Cellular Biochemistry. 332 (1–2): 9–16. doi:10.1007/s11010-009-0168-4. PMID 19507003. S2CID 10508574.
- ^ Palmieri, A.; Pezzetti, F.; Avantaggiato, A.; Lo Muzio, L. L.; Scarano, A.; Rubini, C.; Guerzoni, L.; Arlotti, M.; Ventorre, D.; Carinci, F. (2008). "Titanium Acts on Osteoblast Translational Process". Journal of Oral Implantology. 34 (4): 190–195. doi:10.1563/0.869.1. PMID 18780563.
- ^ Nikiforova, M. N.; Tseng, G. C.; Steward, D.; Diorio, D.; Nikiforov, Y. E. (2008). "MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic Utility". Journal of Clinical Endocrinology & Metabolism. 93 (5): 1600–1608. doi:10.1210/jc.2007-2696. PMC 2386678. PMID 18270258.
External links
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