N2-citryl-N6-acetyl-N6-hydroxylysine synthase
| N2-citryl-N6-acetyl-N6-hydroxylysine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.2.38 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
N2-citryl-N6-acetyl-N6-hydroxylysine synthase (EC 6.3.2.38, N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase, iucA (gene)) is an enzyme with systematic name citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- 2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
This enzyme requires Mg2+.
References
[edit]- ^ Appanna DL, Grundy BJ, Szczepan EW, Viswanatha T (1984). "Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1". Biochim. Biophys. Acta. 801 (3): 437–443. doi:10.1016/0304-4165(84)90150-8.
- ^ Gibson F, Magrath DI (November 1969). "The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I". Biochimica et Biophysica Acta (BBA) - General Subjects. 192 (2): 175–84. doi:10.1016/0304-4165(69)90353-5. PMID 4313071.
- ^ Maurer PJ, Miller M (1982). "Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, N6-acetyl-N6-hydroxylysine". J. Am. Chem. Soc. 104 (11): 3096–3101. doi:10.1021/ja00375a025.
- ^ de Lorenzo V, Bindereif A, Paw BH, Neilands JB (February 1986). "Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12". Journal of Bacteriology. 165 (2): 570–8. doi:10.1128/jb.165.2.570-578.1986. PMC 214457. PMID 2935523.
- ^ Challis GL (April 2005). "A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases". ChemBioChem. 6 (4): 601–11. doi:10.1002/cbic.200400283. PMID 15719346.
External links
[edit]- N2-citryl-N6-acetyl-N6-hydroxylysine+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
