The song's title refers to the digital editing software Adobe Photoshop and how it has been utilized in the cosmetics industry to alter people's images as a marketing ploy for their products. According to frontman Jonathan Higgs, "Photoshop Handsome looks at the world of digital image manipulation and computer game re-incarnation. What would it feel like to come back to life as one of the 'perfected', false, immortal beings that adorn magazine covers, adverts and games?".[2]
For the chart week dated 29 January 2011, "Photoshop Handsome" debuted at number one hundred and twenty-nine on the UK Singles Chart—marking the band's third appearance on the chart; following "Schoolin'" (number 152, 2010) and "My Kz, Ur Bf" (number 121, 2010).[4]