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REG1B

From Wikipedia, the free encyclopedia
REG1B
Identifiers
AliasesREG1B, PSPS2, REGH, REGI-BETA, REGL, regenerating family member 1 beta
External IDsOMIM: 167771; MGI: 97896; HomoloGene: 68517; GeneCards: REG1B; OMA:REG1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006507

NM_009043

RefSeq (protein)

NP_006498

NP_033069

Location (UCSC)Chr 2: 79.09 – 79.09 MbChr 6: 78.37 – 78.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lithostathine-1-beta is a protein that in humans is encoded by the REG1B gene.[5][6]

Function

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This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172023Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023140Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H, Okamoto H (Mar 1994). "Isolation, structural determination and expression of a novel reg gene, human regI beta". Biochim Biophys Acta. 1217 (2): 199–202. doi:10.1016/0167-4781(94)90035-3. PMID 8110835.
  6. ^ a b "Entrez Gene: REG1B regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)".

Further reading

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