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RNF25

From Wikipedia, the free encyclopedia
RNF25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF25, AO7, ring finger protein 25
External IDsOMIM: 616014; MGI: 1890215; HomoloGene: 11193; GeneCards: RNF25; OMA:RNF25 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022453

NM_021313
NM_001305230

RefSeq (protein)

NP_071898

NP_001292159
NP_067288

Location (UCSC)Chr 2: 218.66 – 218.67 MbChr 1: 74.63 – 74.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.[5][6]

Function

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The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NF-κB), and modulate NF-κB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.[6]

Interactions

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RNF25 has been shown to interact with RELA.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163481Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026171Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188.
  6. ^ a b "Entrez Gene: RNF25 ring finger protein 25".

Further reading

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