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SS18L1

From Wikipedia, the free encyclopedia
SS18L1
Identifiers
AliasesSS18L1, CREST, LP2261, nBAF chromatin remodeling complex subunit, SS18L1 subunit of BAF chromatin remodeling complex, SMARCL2
External IDsOMIM: 606472; MGI: 2444061; HomoloGene: 9191; GeneCards: SS18L1; OMA:SS18L1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301778
NM_015558
NM_198935

NM_178750

RefSeq (protein)

NP_001288707
NP_945173

NP_848865

Location (UCSC)Chr 20: 62.14 – 62.18 MbChr 2: 179.68 – 179.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.[5]

Function

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Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene is fused in-frame to the 3-prime end of the SSX1, SSX2, or SSX4 gene. The SS18L1 gene is homologous to SS18.[5]

Interactions

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SS18L1 has been shown to interact with CREB-binding protein.[6] Biochemical pull down assays reveal SS18L1 to interact with several components of the human SWI/SNF chromatin remodeling complex.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184402Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039086Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1".
  6. ^ Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A (January 2004). "Dendrite development regulated by CREST, a calcium-regulated transcriptional activator". Science. 303 (5655): 197–202. Bibcode:2004Sci...303..197A. doi:10.1126/science.1089845. PMID 14716005. S2CID 20879721.
  7. ^ Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE. 7 (3): e33834. Bibcode:2012PLoSO...733834M. doi:10.1371/journal.pone.0033834. PMC 3307773. PMID 22442726.

Further reading

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