TUBA8

TUBA8
Identifiers
Aliases	TUBA8, TUBAL2, tubulin alpha 8, CDCBM8, MACTHC2
External IDs	OMIM: 605742; MGI: 1858225; HomoloGene: 56766; GeneCards: TUBA8; OMA:TUBA8 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	18,146,683 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	121,203,813 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; apex of heart; ; right auricle; ; left ventricle; ; skeletal muscle tissue; ; right hemisphere of cerebellum; ; left testis; ; Brodmann area 9; ; gonad;
	Top expressed in
	muscle of thigh; ; seminiferous tubule; ; triceps brachii muscle; ; temporal muscle; ; medial head of gastrocnemius muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; right ventricle; ; quadriceps femoris muscle; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; structural constituent of cytoskeleton; GTPase activity;
Cellular component	cytoplasm; microtubule; cytoskeleton; microtubule cytoskeleton;
Biological process	microtubule-based process; cytoskeleton organization; microtubule cytoskeleton organization; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	51807
	53857
	ENSG00000183785
	ENSMUSG00000030137
	Q9NY65
	Q9JJZ2
	NM_018943; NM_001193414
	NM_017379
	NP_001180343; NP_061816
	NP_059075
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183785 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030137 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, Lanfranchi G, Valle G (May 2000). "TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse". Biochem Biophys Res Commun. 270 (3): 1111–8. doi:10.1006/bbrc.2000.2571. PMID 10772959.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: TUBA8 tubulin, alpha 8".
^ "GeneCards: TUBA8 gene".

Alexandrova N, Niklinski J, Bliskovsky V, et al. (1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro". Mol. Cell. Biol. 15 (9): 5188–95. doi:10.1128/MCB.15.9.5188. PMC 230766. PMID 7651436.
Feierbach B, Nogales E, Downing KH, Stearns T (1999). "Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin". J. Cell Biol. 144 (1): 113–24. doi:10.1083/jcb.144.1.113. PMC 2148126. PMID 9885248.
Herreros L, Rodríguez-Fernandez JL, Brown MC, et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". J. Biol. Chem. 275 (34): 26436–40. doi:10.1074/jbc.M003970200. hdl:10261/135387. PMID 10840040.
Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
Saugstad JA, Yang S, Pohl J, et al. (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". J. Neurochem. 80 (6): 980–8. doi:10.1046/j.0022-3042.2002.00778.x. PMC 2925652. PMID 11953448.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Xu Y, Kulkosky J, Acheampong E, et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070–5. Bibcode:2004PNAS..101.7070X. doi:10.1073/pnas.0304859101. PMC 406467. PMID 15103018.
Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology. 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M, et al. (2006). "Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection". Mol. Biol. Cell. 16 (11): 5445–54. doi:10.1091/mbc.E05-04-0354. PMC 1266439. PMID 16148047.
Canani RB, De Marco G, Passariello A, et al. (2006). "Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells". AIDS. 20 (1): 5–10. doi:10.1097/01.aids.0000198088.85572.68. PMID 16327313. S2CID 21499158.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183785 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030137 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10772959-5] Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, Lanfranchi G, Valle G (May 2000). "TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse". Biochem Biophys Res Commun. 270 (3): 1111–8. doi:10.1006/bbrc.2000.2571. PMID 10772959.

[pmid10591208-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-7] "Entrez Gene: TUBA8 tubulin, alpha 8".

[genecards-8] "GeneCards: TUBA8 gene".

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References

Further reading