Talk:Melittin

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Melitten vs Melittin vs Melitin

I am opening discussion on the spelling of this word. The page was moved from the previous spelling months ago, and yet the spelling throughout the page has not been changed. Additionally the journal articles use the previous spelling, is this a mistake? Any thoughts of moving it back? eximo (talk) 06:02, 30 September 2009 (UTC)[reply]

It seems that google web and scholar searches favour "Melittin". The article should favour common usage so I will move it back. -- Alan Liefting (talk) - 06:37, 30 September 2009 (UTC)[reply]

Whether google scholar or others favour Melittin spelling or another one is less relevant than word forming rules. In this case the word derives from Meli (meaning honey in Greek) and -itin, small complex substance coming out of the first (meli in our case). Examples are Chitin, Keratin, Ferritin. In all these -itin is with one "t". Therefore the right pronounciation is "Melitin", with one "t". There is also a saint after the same name Santa (or Hagia) Melitini, celebrated at the 29th of October, which shows the right spelling. I suggest a change of the name, deleting one "t", if we agree on this.

"Melittin" is by far the most common spelling in the medical literature, shown by this search result from PubMed, indicating "melittin" is the most prevalent term since the early 1970s. The US National Library of Medicine service for chemical compounds, 'PubChem' also has its main article under "melittin", although all 3 spellings are noted and can be found in the literature. The article name as it's spelled now should not be changed. --Zefr (talk) 14:02, 30 October 2019 (UTC)[reply]

Protein sequence

The protein sequence is GIGAVLKVLTTGLPALISWIKRKRQQ John Moser (talk) 12:39, 27 May 2019 (UTC)[reply]

Thanks, but is already linked via PubChem link, see https://pubchem.ncbi.nlm.nih.gov/compound/16133648#section=Biologic-Description

Done KR 17387349L8764 (talk) 14:59, 30 June 2021 (UTC)[reply]

Potential cancer treatment

It's early days, of course, but it seems melittin might work as a chemo agent for some lung and breast cancers. https://www.sciencealert.com/bees-formidable-weapons-could-successfully-target-aggressive-breast-cancer 203.13.3.89 (talk) 03:22, 4 September 2020 (UTC)[reply]

Yes, a number of research sources exist, see for example https://pubmed.ncbi.nlm.nih.gov/?term=melittin+tumor&filter=years.2015-2021 or https://www.sciencedirect.com/search?qs=melittin%20tumor ... you could add it if you specifically write about it and add specific references, but the topic seems not so new and probably can be extended to various other peptides or the general research into peptides and applications. Sciencealert is always full of hyper stuff, I recommend equalizing it accordingly. BR 17387349L8764 (talk) 15:05, 30 June 2021 (UTC)[reply]

limited scientific research on its potential effects

The research is limited? Does ref 7 proof this in particular? I see a stable research on-going. See for example https://pubmed.ncbi.nlm.nih.gov/?term=melittin, or the yearly publication numbers https://www.sciencedirect.com/search?qs=melittin. Maybe the tumor-related research is limited, but the meaning is different and has to be made clear. The paper (ref 7) also reads "non-specific cytotoxicity and hemolytic activity". BR 17387349L8764 (talk) 15:15, 30 June 2021 (UTC)[reply]

All preliminary research too early-stage to discuss, with no rigorous clinical research published to date. Needs a WP:MEDRS review for the encyclopedia (note: no such review exists). Zefr (talk) 16:35, 30 June 2021 (UTC)[reply]

Meleten

This form of 89.198.64.100 (talk) 17:10, 3 September 2022 (UTC)[reply]