Talk:Mertansine

Pharmacology Low‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology articles
Low	This article has been rated as Low-importance on the project's importance scale.

Chemicals Low‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
Low	This article has been rated as Low-importance on the project's importance scale.

emtansine

Is Mertansine (DM1) the same as emtansine - as in Trastuzumab emtansine, an antibody-drug conjugate for the treatment of HER2+ metastatic breast cancer. ? Rod57 (talk) 22:55, 23 March 2011 (UTC)[reply]

According to http://www.who.int/medicines/services/inn/RadicalBook2010.pdf, those are two different entities. Maybe the equation DM1=mertansine is wrong. --ἀνυπόδητος (talk) 08:13, 24 March 2011 (UTC)[reply]

OK, here's the solution: DM1 (probably called maytansine, but I haven't found a source yet) is the structure in File:Mertansine mab structure.svg up to the disulfide, and including one of the sulfur atoms. If it is linked to the MAB as in the mentioned image (disulfide bridge to an ~~amino~~pentanioc acid), the MAB is called "—mab mertansine". If it's linked as in http://www.who.int/medicines/services/inn/RadicalBook2010.pdf (p 63, a more complicated linker with 2 rings), the MAB is called "—mab emtansine" as in Trastuzumab emtansine. Will try to sort this out when I've got the time. --ἀνυπόδητος (talk) 10:57, 24 March 2011 (UTC)[reply]

Could move to DM1

or Maytansinoid DM1 since Mertansine and emtansine only differ by a linker. Can describe the cytotoxic mechanism on this shared page ? - Rod57 (talk) 12:24, 23 September 2015 (UTC)[reply]

Emtansine and Maytansinoid DM1 already redirect here, or am I missing something? I'll add a bit about mechanism, though. Thanks for the suggestion. --ἀνυπόδητος (talk) 15:17, 24 September 2015 (UTC)[reply]

External links modified (January 2018)

Hello fellow Wikipedians,

I have just modified one external link on Mertansine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

Added archive https://web.archive.org/web/20101020064034/http://www.immunogen.com/wt/page/trastuzumab_DM1 to http://www.immunogen.com/wt/page/trastuzumab_DM1

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 09:44, 26 January 2018 (UTC)[reply]