Talk:PRL-8-53

Mechanism of Action Section

The mechanism of action section is a little contradictory; a substance cannot potentiate dopamine while not potentiating amphetamines. By definition potentiation of amphetamines is caused by potentiation of dopamine, as dopamine is their principle method of action. I think the section would be better read something along the lines of "Studies are contradictory whether PRL-8-53 can potentiate dextroamphetamine. It can be assumed that any potentiatiating action is minor based on no external signs of dextroamphetamine potentiation." LiamSP (talk) 03:07, 3 January 2014 (UTC)

This simply isn't true. A substance can indeed potentiate dopamine without potentiating amphetamine- basically, dopamine potentiation of one substance can be overwhelmed by another (especially such strong dopamine potentiator as amphetamines). Note also "potentiate" is not the same as "additive effect". "Potentiate" means the effects are increased beyond what is expected of individual effects. For example, Modafinil has a eugeroic effect (wakefulness) that will not increase or potentiate amphetamines' eugeroic effects. They will simply co-exist in the subject in proportion to dosage. On the other hand, sodium bicarbonate will potentiate amphetamines' stimulating effects without providing any stimulating effect by itself. I'm not sure if the confusion here is based on this common misunderstanding of term. However, I believe the suggested rewrite would require a separate citation of its own Cuvtixo (talk) 05:23, 19 February 2019 (UTC)

the study

i blanked the entire nootropic effects section because it was terrible, pretty much. elaboration in edit summary. im posting in the talk page to clarify that the study is relevant and can be incorporated into the article, but until someone does so in the proper way it should stay removed. 216.164.249.213 (talk) 10:45, 11 July 2024 (UTC)