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Professor Byer played a major role in the success of three laser technology companies. Quanta-Ray commercialized a high-energy pulsed laser invented in the Byer lab[1] which is still widely used in scientific research. Quanta-Ray was acquired by Spectra-Physics in 1981[2] and is now a part of Newport Corporation. Byer was a founder of Lightwave Electronics, a pioneering designer and manufacturer of diode-pumped solid-state lasers, which was acquired by JDS Uniphase in 2005[3] and is now a part of Lumentum. He played a similar role at Mobius Photonics, which produced pulsed fiber lasers, and was acquired by IPG Photonics in 2013[4].

Professor Byer led Stanford University's contributions to the Laser Interferometer Gravitational Wave Observatory, which made the first-ever detection of a disturbance in space-time caused by a pair of merging black holes on September 14, 2015.