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Standard Turbidity Curves are curves that measure absorbance change over time and is marked by linear and horizontal growth.[1] Overall, the graph is
characterized by an initial lag phase, a steady state where binding grows infinitesimally or not at all, and a slope that represents the rate of assembly.[2] Standard turbidity curves are known to vary due to change in pH, concentration, temperature, and timing. Standard Turbidity Curves are based off the established theory of classic light scattering theory, and uses basic calculations off this theory to measure turbidity growth phase.[1] The kinect rate constants of assembly and disassembly have been studied for collagen fibrillogenesis, neurotubles, the aggregation of αs-casien, assembly of tobacco mosaic virus protein, and the gelation of sickle cell hemoglobin. [1]
Basic Research Collagen is used in laboratory studies for cell culture, studying cell behavior and cellular interactions with the extracellular environment.[3] Currently, studies have been conducted to enhance the understanding of collagen at a monomer level.[4] It is believed that collagen and fibronectin have a codependent relationship, where they rely on each other with the extracellular matrix. It is believed that if this mechanism is understood the idea behind regenerative medicine, focusing on how to not only rebuild a tissue after being damaged, but additionally return it back to its original function.[5]
- ^ a b c SILVER, FREDERICK H.; BIRK, DAVID E. (September 1983). "Kinetic Analysis of Collagen Fibrillogenesis: I. Use ofTurbidityTime Data". Collagen and Related Research. 3 (5): 393-405.
- ^ Zhu, Jieling (15 April 2014). "Collagen I Self-Assembly: Revealing the Developing Structures that Generate Turbidity".
{{cite journal}}: Cite journal requires|journal=(help) - ^ Blow, Nathan (2009). "Cell culture: building a better matrix". Nature Methods. 6 (8): 619–622. doi:10.1038/nmeth0809-619.
- ^ Schwarzbauer, J. E., J. E (1999). "Fibronectin fibrillogenesis: a paradigm for extracellular matrix assembly. Current opinion in cell biology, 11(5), 622-627".
{{cite journal}}: Cite journal requires|journal=(help) - ^ Pawelec, K.M. (2016). "Collagen: a network for regenerative medicine". Journal of Materials Chemistry B. 4(40): 6484–6496.