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Environmental Factors of ASD

Maternal immune activation has also been associated with increased risk for development of neurodevelopmental disorders.[1] Maternal immune activation is when inflammatory pathways are activated during pregnancy, usually by an infection. These inflammatory pathways involve the release of cytokines[2], or immune signaling proteins. Injection of Poly(I:C)[3], which is an immunostimulant[4] and mimics viral infection, to pregnant rodents has been shown to induce an inflammatory response in the brain of the offspring, induce structural brain changes in the offspring, and bring about behavioral changes such as hyperactivity, more aggressive behavior, and less social behavior in the offspring.[5] In addition to viral infection, lipopolysaccharides[6] (LPS) has been used to mimic bacterial infection in rodents in order to observe the effects on the offspring. LPS had similar effects as Poly(I:C) on the immune system of the offspring, increasing inflammation.[7] This inflammatory state in the offspring lasted until adulthood, indicating the long-lasting effects of maternal immune activation.[7] Overall, recent studies make a case for infection during pregnancy being an environmental risk factor for neurodevelopmental disorders such as ASD or schizophrenia in rodents.

  1. ^ Haddad, Faraj L.; Patel, Salonee V.; Schmid, Susanne (June 2020). "Maternal Immune Activation by Poly I:C as a preclinical Model for Neurodevelopmental Disorders: A focus on Autism and Schizophrenia". Neuroscience and Biobehavioral Reviews. 113: 546–567. doi:10.1016/j.neubiorev.2020.04.012. ISSN 1873-7528. PMID 32320814.
  2. ^ "Cytokine", Wikipedia, 2021-01-21, retrieved 2021-04-15
  3. ^ "Polyinosinic:polycytidylic acid", Wikipedia, 2020-04-02, retrieved 2021-04-15
  4. ^ "Immunostimulant", Wikipedia, 2021-01-21, retrieved 2021-04-15
  5. ^ Goh, Jen-Yin; O'Sullivan, Saoirse E.; Shortall, Sinead E.; Zordan, Nicole; Piccinini, Anna M.; Potter, Harry G.; Fone, Kevin C. F.; King, Madeleine V. (2020-10-01). "Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat 'dual-hit' model for neurodevelopmental disorders". Brain, Behavior, and Immunity. 89: 100–117. doi:10.1016/j.bbi.2020.05.076. ISSN 0889-1591.
  6. ^ "Lipopolysaccharide", Wikipedia, 2021-04-05, retrieved 2021-04-16
  7. ^ a b Talukdar, Pinku Mani; Abdul, Fazal; Maes, Michael; Binu, V. S.; Venkatasubramanian, Ganesan; Kutty, Bindu M.; Debnath, Monojit (October 2020). "Maternal Immune Activation Causes Schizophrenia-like Behaviors in the Offspring through Activation of Immune-Inflammatory, Oxidative and Apoptotic Pathways, and Lowered Antioxidant Defenses and Neuroprotection". Molecular Neurobiology. 57 (10): 4345–4361. doi:10.1007/s12035-020-02028-8. ISSN 1559-1182. PMID 32720073.
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