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mir-46/mir-47/mir-281 microRNA precursor family

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mir-46/mir-47/mir-281 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-46
Identifiers
Symbolmir-46
RfamRF00249
miRBaseMI0000017
miRBase familyMIPF0000087
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

In molecular biology, mir-46 (MI0000017) and mir-47 (MI0000018) are microRNA expressed in C. elegans from related hairpin precursor sequences.[1] The predicted hairpin precursor sequences for Drosophila mir-281 (MI0000366, MI0000370)[2][3] are also related and, hence, belong to this family. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequences are expressed from the 3' arms of the hairpin precursors.

References

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  1. ^ Lau NC, Lim LP, Weinstein EG, Bartel DP (October 2001). "An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans". Science. 294 (5543): 858–62. doi:10.1126/science.1065062. PMID 11679671. S2CID 43262684.
  2. ^ Lai EC, Tomancak P, Williams RW, Rubin GM (2003). "Computational identification of Drosophila microRNA genes". Genome Biology. 4 (7): R42. doi:10.1186/gb-2003-4-7-r42. PMC 193629. PMID 12844358.
  3. ^ Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T (August 2003). "The small RNA profile during Drosophila melanogaster development". Developmental Cell. 5 (2): 337–50. doi:10.1016/S1534-5807(03)00228-4. hdl:11858/00-001M-0000-0010-94E8-6. PMID 12919683.
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